CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever

Arora, Gunjan; Lynn, Geoffrey E.; Tang, Xiao‐Tian; Hoornstra, Dieuwertje; Sajid, Andaleeb; Hovius, Joppe W.; Palm, Noah W.; Ring, Aaron M.; Fikrig, Erol

doi:10.1128/mbio.01161-22

Cited by 5 publications

(1 citation statement)

References 74 publications

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“…The selected genes expression heatmap was further plotted by ggplot2 (R sutdio) and Prism v8 (Graphpad). The selected immune pathways were further plotted on a bubble diagram by ggplot2 (version 3.3.5) in R Statistical Software (v4.1.2) as described previously[ 72 , 73 ]. The network analysis was performed in String database [ 74 , 75 ].…”

Section: Methodsmentioning

confidence: 99%

mosGILT controls innate immunity and germ cell development in Anopheles gambiae

Arora,

Tang,

Cui

et al. 2024

BMC Genomics

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Gene-edited mosquitoes lacking a gamma-interferon-inducible lysosomal thiol reductase-like protein, namely (mosGILTnull) have lower Plasmodium infection, which is linked to impaired ovarian development and immune activation. The transcriptome of mosGILTnull Anopheles gambiae was therefore compared to wild type (WT) mosquitoes by RNA-sequencing to delineate mosGILT-dependent pathways. Compared to WT mosquitoes, mosGILTnull A. gambiae demonstrated altered expression of genes related to oogenesis, 20-hydroxyecdysone synthesis, as well as immune-related genes. Serendipitously, the zero population growth gene, zpg, an essential regulator of germ cell development was found to be one of the most downregulated genes in mosGILTnull mosquitoes. These results provide a crucial missing link between two previous studies on the role of zpg and mosGILT in ovarian development. This study further demonstrates that mosGILT has the potential to serve as a target for the biological control of mosquito vectors and to influence the Plasmodium life cycle within the vector.

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