Cd8^high+ (CD57+) T cells in patients with rheumatoid arthritis

Abstract

Objective. To investigate the development and T cell receptor (TCR) usage of CD8+, CD57+ T cells in rheumatoid arthritis (RA) patients.Methods. Three-color flow cytometry using monoclonal antibodies (MAb) to CD8, CD57 and different TCR V, gene products.Results. The proportion of CD8+ T cells expressing CD57 (CD57/CDS) was significantly higher in RA patients compared with age-matched controls. Expanded TCR V, populations were more frequent, and were found in both RA patient-derived CDShigh+ (CD57+) and CDS+, CD57-populations. TCR V,5+ and TCR V,13+ expansions were present at high frequency (5 of 26 and 7 of 26, respectively). TCR V, expansions in CDShigh+ (CD57+) lymphocytes from RA patients were significantly larger than those in age-matched controls (expansion index 2.38 f 0.28, n = 41 and 1.63 f 0.09, n = 32, respectively), and were stable over time.Conclusion. RA leads to an increase in the frequency of expanded CD8+ T cell subsets expressing selected TCR, due to expansion of TCR V,+ populaPreliminary data from this study were presented as a poster at the 9th International Immunology Congress, San Francisco, California, 1995.

Involvement of CD4+,CD57+ T cells in the disease activity of rheumatoid arthritis

“…As has been previously reported (6,7), the frequencies of CD57ϩ T cells both in the CD4ϩ subset and in the CD8ϩ subset were significantly in- creased in RA patients (6.0% in CD4 subset, 32.6% in CD8 subset) compared with those in the controls (3.3% in CD4 subset, 20.9% in CD8 subset). Among the laboratory parameters studied, ESR had a significant correlation with the frequency of CD4ϩ,CD57ϩ T cells (Figure 1).…”

“…The notion that there may be some association of CD57ϩ T cells with the pathophysiology of rheumatoid arthritis (RA) comes from the fact that the number of CD57ϩ T cells is often increased in the peripheral blood, joint fluid, and joint-adjacent bone marrow of RA patients (6,7). Moreover, the lymphoproliferative disorder of LGLs expressing both CD3 and CD57 antigens (T-LGL leukemia) is known to be complicated by the symptoms of RA (1).…”

“…Moreover, the lymphoproliferative disorder of LGLs expressing both CD3 and CD57 antigens (T-LGL leukemia) is known to be complicated by the symptoms of RA (1). A number of studies have demonstrated oligoclonality of these CD57ϩ T cells, indicating that the high frequency of the CD57ϩ T cells in RA patients reflects the in vivo clonal expansion of these cells in response to still-unknown antigens (6). Although these facts suggest that CD57ϩ T cells are involved in the pathophysiology of RA, there is little information as to how the circulating CD57ϩ T cells contribute to disease manifestations in RA, and, to our knowledge, there has been no report evaluating the cytokine profile of CD57ϩ T cells in RA patients.…”

CD8+ Immunosenescence Predicts Post-Transplant Cutaneous Squamous Cell Carcinoma in High-Risk Patients

“…12,36,37 Chronic antigenic stimulation, such as viral infection or autoimmune disease, is associated with an accumulation of senescent and terminally differentiated T cells. [38][39][40][41][42] We demonstrate that CD57 expression in cytomegalovirus seropositive RTRs also directly correlates with the titer of anticytomegalovirus IgG. Excess immunosuppression may lead to repeated episodes of subclinical viral reactivation and inflammation over time, leading to the accumulation of oligoclonally expanded senescent T cells that effectively reduces the T cell antigen repertoire.…”

Immune and myodegenerative pathomechanisms in inclusion body myositis

“…Aside from lacking CD28‐expression, expression of the terminally sulfated glycan carbohydrate CD57 is generally regarded as a marker for terminal differentiation and clonal exhaustion on CD8 + T cells and this T cell subset is commonly oligoclonally expanded during conditions of chronic immune activation 85, 86, 87. CD8 + CD57 + T cell frequencies are especially increased in the elderly, they have strong cytotoxic potential, high expression of adhesion molecules, strong migratory potential toward nonlymphoid organs and – indicative of a cytotoxic effector memory phenotype – they depict expression of CX3CR1.…”