CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.

Wang, E. C. Y.; Moss, Paul; Frodsham, P; Lehner, Paul J.; Bell, John I.; Borysiewicz, L. K.

doi:10.4049/jimmunol.155.10.5046

Cited by 142 publications

(2 citation statements)

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“…Percentages of CD4+ and CD8+ T cells with the CD28+CD57− phenotype were significantly loweramong CMV-seropositive as compared to -seronegative subjects, while percentages of CD4+ and CD8+ T cells with the CD28−CD57+ phenotype were significantly higher among seropositive as compared to seronegative subjects (Table 2). These results are in agreement with those reported by others [12,34,36,39,41]. Our study further demonstrated marginal associations of CD8+CD28−CD57+ T cells with a pathological diagnosis of Alzheimer disease (by NIA-Reagan criteria) and CD4+CD28−CD57+ T cells with accumulation of Aβ (Table 3).…”

Section: Discussionsupporting

confidence: 93%

“…Cryopreserved PBMCs from CMV-seropositive subjects were analyzed by flow cytometry to determine the percentages of CMV-specific CD4+ and CD8+ T cells by intracellular expression of IFN-γ and TNF-α in response to the CMV-specific antigen, pp65. Cells positive for both cytokines were detected in CD8+ and CD4+ T-cell subsets in all samples; however, mean percentages (Table 2) were lower than reported elsewhere [7,[33][34][35][36]. One possible reason for the lower detectable response rate was the use of only a single CMV-specific antigen in the assay.…”

Section: Cmv-specific T Cellsmentioning

confidence: 60%

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Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

Lurain¹,

Hanson²,

Martinson³

et al. 2013

The Journal of Infectious Diseases

138

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Serum, cerebrospinal fluid (CSF), and cryopreserved lymphocytes from subjects in the Rush Alzheimer's Disease Center Religious Orders Study were analyzed for associations between cytomegalovirus (CMV) infection and clinical and pathological markers of Alzheimer disease. CMV antibody levels were associated with neurofibrillary tangles (NFTs). CSF interferon γ was only detected in seropositive subjects and was significantly associated with NFTs. The percentage of senescent T cells (CD4+ or CD8+CD28-CD57+) was significantly higher for CMV-seropositive as compared to CMV-seronegative subjects and was marginally associated with the pathologic diagnosis of Alzheimer disease (CD4+) or amyloid-β (CD8+). Immunocytochemical analysis showed induction of amyloid-β in human foreskin fibroblasts (HFFs) infected with each of 3 clinical CMV strains. In the same subjects, there was no association of herpes simplex virus type 1 (HSV-1) antibody levels with CMV antibody levels or clinical or pathological markers of Alzheimer disease. HSV-1 infection of HFFs did not induce amyloid-β. These data support an association between CMV and the development of Alzheimer disease.

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Section: Discussionsupporting

confidence: 93%

Section: Cmv-specific T Cellsmentioning

confidence: 60%

Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

Lurain¹,

Hanson²,

Martinson³

et al. 2013

The Journal of Infectious Diseases

138

View full text Add to dashboard Cite

show abstract

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

et al. 1999

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In humans, NK receptors are expressed by natural killer cells and some T cells, the latter of which are preferentially alphabetaTCR+ CD8+ cytolytic T lymphocytes (CTL). In this study we analyzed the expression of nine NK receptors (p58.1, p58.2, p70, p140, ILT2, NKRP1A, ZIN176, CD94 and CD94/NKG2A) in PBL from both healthy donors and melanoma patients. The percentages of NK receptor-positive T cells (NKT cells) varied strongly, and this variation was more important between individual patients than between individual healthy donors. In all the individuals, the NKT cells were preferentially CD28-, and a significant correlation was found between the percentage of CD28- T cells and the percentage of NK receptor+ T cells. Based on these data and the known activated phenotype of CD28- T cells, we propose that the CD28- CD8+ T cell pool represents or contains the currently active CTL population, and that the frequent expression of NK receptors reflects regulatory mechanisms modulating the extent of CTL effector function. Preliminary results indicate that some tumor antigen-specific T cells may indeed be CD28- and express NK receptors in vivo.

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Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

et al. 1999

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Chronic antigenic stimulation has been associated with peripheral blood expansions of CD8pos. T cells characterized by CD57 expression, loss of CD27 expression, and reversal of the CD45RObright /RAdim phenotype usually associated with immunological memory towards a CD45ROdim /RAbright phenotype. However, the relationship and functional significance of these subset(s) has remained controversial. Here, this issue was addressed using a novel flow cytometric technique that allows simultaneous detection of human cytomegalovirus (HCMV)‐specific CD8pos. memory T cells by rapid (< 6 h) HCMV peptide‐specific induction of cytokine synthesis, and their phenotypic characterization, including CD57, CD27 and CD45RA/RO. The vast majority of resting CD8pos. T cells capable of rapid induction of IFN‐γ and TNF‐α synthesis in response to HCMV peptides were found in a subset characterized by intermediate to high expression of CD57, down‐regulation/loss of CD27, and varying degrees of reversal of the classical “memory” CD45RObright /RAdim phenotype. This subpopulation likely includes the fully differentiated memory cells responsible for the long‐term immune defense against HCMV reactivation.

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CD8highCD57+ T lymphocytes in normal, healthy individuals are oligoclonal and respond to human cytomegalovirus.

Cited by 142 publications

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Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

Virological and Immunological Characteristics of Human Cytomegalovirus Infection Associated With Alzheimer Disease

CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients

Distribution of human CMV-specific memory T cells among the CD8pos. subsets defined by CD57, CD27, and CD45 isoforms

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