CD95/Fas expression on peripheral blood T lymphocytes in patients with multiple sclerosis: effect of high-dose methylprednisolone therapy

Petelin, Željka; Brinar, Vesna; Petravić, Damir; Zurak, Niko; Dubravčić, Klara; Batinić, Drago

doi:10.1016/j.clineuro.2004.02.011

Cited by 15 publications

(5 citation statements)

References 16 publications

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“…Also, the nuclear factor of activated T cell (NFAT) transcription factor is involved in the regulation of T-cell development, activation and differentiation 26 . Moreover, our results are in line with observations in patients with relapsing-remitting MS that suggest an increase of circulating CD95 −/lo CD4 + and CD8 + T cells compared to healthy controls 27,28 . We also identified increased abundance of IL-6-expressing CD8a − CD47 hi IKZF1 hi T cells in the peripheral blood of patients with early MS.…”

Section: Discussionsupporting

confidence: 92%

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Böttcher

Fernández-Zapata

Schlickeiser

et al. 2019

Sci Rep

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Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). Studies in rodent models demonstrated an association of CNS-infiltrating monocyte-derived macrophages with disease severity. However, little is known about humans. Here, we performed an exploratory analysis of peripheral blood mononuclear cells (PBMCs) isolated from healthy controls and drug-naïve patients with early MS using multiplexed single-cell mass cytometry and algorithm-based data analysis. Two antibody panels comprising a total of 64 antibodies were designed to comprehensively analyse diverse immune cell populations, with particular emphasis on monocytes. PBMC composition and marker expression were overall similar between the groups. However, an increased abundance of CCR7+ and IL-6+ T cells was detected in early MS-PBMCs, whereas NFAT1hiT-bethiCD4+ T cells were decreased. Similarly, we detected changes in the subset composition of the CCR7+ and MIPβhi HLA-DR+ lymphocyte compartment. Only mild alterations were detected in monocytes/myeloid cells of patients with early MS, namely a decreased abundance of CD141hiIRF8hiCXCR3+CD68− dendritic cells. Unlike in Crohn’s disease, no significant differences were found in the monocyte fraction of patients with early MS compared to healthy controls. This study provides a valuable resource for future studies designed to characterise and target diverse PBMC subsets in MS.

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Section: Discussionsupporting

confidence: 92%

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Böttcher

Fernández-Zapata

Schlickeiser

et al. 2019

Sci Rep

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“…[66]. The corticosteroid methylprednisolone is used to treat acute relapses in relapsing-remitting MS and has recently been shown to influence CD95/Fas expression on CD8+ and CD4+ T lymphocytes in treated patients [67].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Immunological Approaches to Prevent Neuronal Apoptosis During Neuroinflammation

Murphy¹,

Keating²,

Sheehan³

et al. 2005

CMCAIAA

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Neurodegeneration is set to increase in parallel with society's age demographics. With the increasing appreciation of the role played by apoptosis in neurodegeneration, much effort has gone into understanding key effectors in this process and to develop therapies that reduce neuronal apoptosis, thus preserving the integrity of the CNS. In contrast to peripheral apoptosis, inflammation is commonly seen to co-localize with apoptotic sites in the CNS however investigators are unsure whether inflammation is the primary cause for neuronal apoptosis induction or whether it is secondary. This current review highlights the role of apoptosis in neurodegenerative diseases, examines the evidence as to whether inflammation is a causative or consequential event in neuronal apoptosis and describes some of the immunological approaches that are currently in the clinic or being developed.

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“…Между тем результаты исследований позволяют предположить, что они могут включать повышенное накопление в крови растворимых форм рецепторов FAS/APO-1 (sFas/APO-1), блокирующих взаимодействие мембранных рецепторов Fas/APO-1 с Fas-лигандом [10][11][12][13], а также нарушение экспрессии FAS/APO-1 и/или Fas-лиганда на лимфоцитах [14][15][16][17][18]. Имеются данные, что уровень экспрессии FAS/APO-1 различен при ремиттирующем и вторично-прогрессирующем течении РС [17] и изменяется при обострении заболевания [19], терапии метилпреднизолоном [20] и интерфероном бета [14].…”

Section: Introductionunclassified

The association of the FAS/APO-1 (rs2234767) gene polymorphism with the risk and rapid progression of multiple sclerosis

Nochevnaya¹,

Переверзева²,

Соколова³

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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CD95/Fas expression on peripheral blood T lymphocytes in patients with multiple sclerosis: effect of high-dose methylprednisolone therapy

Cited by 15 publications

References 16 publications

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

Immunological Approaches to Prevent Neuronal Apoptosis During Neuroinflammation

The association of the FAS/APO-1 (rs2234767) gene polymorphism with the risk and rapid progression of multiple sclerosis

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