CDKL3 Promotes Non-small Cell Lung Cancer by Suppressing Autophagy Via Activation of PI3K/Akt/mTOR Pathway

Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate

“…A brief bibliographic study of these off-targets suggests that Leucettinibs could be optimized toward some of them and become useful reagents to evaluate and understand their functions or reassigned to new applications. For example, CDKL3 has ciliary and neuronal morphogenesis functions, and its inhibition displays anticancer activities. − CDKL4 also has ciliary function by regulating the ciliary proximal segment length . TAF1L contributes to the development of various cancers. − TRB2 may be involved in Mcl1-dependent apoptosis, macrophage IL-10 production, inflammatory activation of monocytes, and in pro- or anti-cancer regulation. , TRB2 is a pseudokinase that binds ATP and autophosphorylates in a metal-independent manner .…”

CK1δ/ε inhibition induces ULK1-mediated autophagy in tumorigenesis

“…Undoubtedly, this process involving metabolism and nutrient utilization has an important impact on the development and treatment of cancer. Autophagy inhibition contributes to cancer progression in various cancers including endometrial cancer, prostate cancer, lung cancer, and so forth [8] , [9] , [10] . At the same time, enhancing autophagy has been proven feasible to achieve anticancer activities [ 11 , 12 ].…”