CDKN2B - AS may indirectly regulate coronary artery disease-associated genes via targeting miR - 92a

Cheng, Ming; An, Shoukuan; Li, Junquan

doi:10.1016/j.gene.2017.07.070

Cited by 23 publications

(17 citation statements)

References 40 publications

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“…Unfortunately, there were no other reports about the lncRNAs targeted by miR-92a-3p in glioma. However, CDKN2B-AS was involved in the pathogenesis of coronary artery disease by targeting miR-92a-3p through GATA2, MAP1B and ARG1 regulation [ 49 ]. The TMZ is commonly used as the first-line therapy for glioma treatment, however, its resistance represents a major clinical challenge that leads to tumor relapse or progress.…”

Section: Discussionmentioning

confidence: 99%

The long non-coding RNA SNHG14 inhibits cell proliferation and invasion and promotes apoptosis by sponging miR-92a-3p in glioma

et al. 2018

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Malignant glioma is one of the most common types of primary brain tumours. Long non-coding RNAs (lncRNAs) have recently emerged as a new class of therapeutic targets for many cancers. In this study, we aimed to explore the functional involvement of small nucleolar RNA host gene 14 (SNHG14) and its potential regulatory mechanism in glioma progression. SNHG14 was found to be downregulated in human glioma tissues and cell lines. SNHG14 significantly inhibited cell viability, reduced cell invasion, and induced apoptosis in glioma cell lines. Furthermore, a correlation analysis demonstrated that there was a negative correlation between SNHG14 expression and miR-92a-3p expression. Bioinformatics prediction and luciferase reporter assays demonstrated that miR-92a-3p could directly bind to SNHG14. miR-92a-3p was significantly upregulated in glioma and acted as an oncogene in glioma cells by inhibiting Bim. Moreover, mechanistic investigations showed that miR-92a-3p could reverse the tumour suppressive effects induced by SNHG14 in glioma, indicating that SNHG14 may act as an endogenous sponge that competes for binding to miR-92a-3p. Our results suggest that SNHG14 and miR-92a-3p may be promising molecular targets for glioma therapy.

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Section: Discussionmentioning

confidence: 99%

The long non-coding RNA SNHG14 inhibits cell proliferation and invasion and promotes apoptosis by sponging miR-92a-3p in glioma

et al. 2018

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“…Stuart and coworkers showed that miR-323b-5p levels were increased in familial combined hyperlipidemia patients and that this miRNA could induce lipid accumulation in 3T3-L1 cells by reducing endogenous CDKN2B (cyclin-dependent kinase 4 2B) protein levels 61 , suggesting that CDKN2B may participate in adipose tissue metabolism. Furthermore, a recent study showed that CDKN2B RNA may indirectly regulate CAD-associated genes via targeting miR-92a 62 . Our results showed that CDKN2B was one of the 92 possible target genes of miR-323b-5p.…”

Section: Discussionmentioning

confidence: 99%

MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients

Wang

et al. 2018

Sci Rep

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Type 2 diabetes mellitus (T2DM) is a major contributor to peripheral artery disease (PAD), especially in cases that advance to critical limb ischemia (CLI). Accumulating evidence indicates that miRNAs play an important role in the development of PAD and T2DM. Due to the limited value of current diagnostic methods for CLI in T2DM patients, we compared the miRNA expression profiles of Chinese T2DM patients with or without CLI to find out whether distinctive miRNAs could serve as potential diagnostic biomarkers. We statistically identified 7 miRNAs (hsa-miR-200b-3p, hsa-miR-2115-3p, hsa-miR-431-5p, hsa-miR-486-5p, hsa-miR-210-3p, hsa-miR-1264, hsa-miR-323b-5p) which were up-regulated in the CLI group, whereas other 4 miRNAs (hsa-miR-5579-3p, hsa-miR-665, hsa-miR-4285, hsa-miR-500a-3p) were down-regulated. Our validation test suggested a relatively high diagnostic accuracy of serum hsa-miR-323b-5p levels for the detection of CLI in T2DM patients, with a sensitivity of 62.67% and a specificity of 80.65%. The area under the curve (AUC) for miR-323b-5p + confounding risk factors was 0.94 (95% CI: 0.884–0.994, P < 0.001), which was higher than that for miR-323b-5p. Taken together, our results indicate that circulating hsa-miR-323b-5p could be a promising serum biomarker for the diagnosis of critical limb ischemia in type 2 diabetic patients.

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“…ANRIL has been shown to be involved in cis ‐ and trans ‐regulation of the expression of different genes following RNA interference, gene silencing, or epigenetic mechanisms, such as chromatin remodeling or DNA methylation . The expression of ANRIL, is among others, under genetic control . Many different genetic variants of ANRIL have been identified .…”

Section: Introductionmentioning

confidence: 99%

“…Many different genetic variants of ANRIL have been identified . ANRIL was shown to be involved in different systemic diseases, including cancer, inflammatory bowel disease, CVD, and periodontal disease . The impact of genetic characteristics of ANRIL on different inflammatory diseases was studied in genome‐wide association studies, as well as in large‐scale candidate gene studies .…”

Section: Introductionmentioning

confidence: 99%

“…ANRIL was shown to be involved in different systemic diseases, including cancer, inflammatory bowel disease, CVD, and periodontal disease . The impact of genetic characteristics of ANRIL on different inflammatory diseases was studied in genome‐wide association studies, as well as in large‐scale candidate gene studies . In a study by Schaefer et al, 51 tagging single nucleotide polymorphisms (SNPs) at the ANRIL locus were investigated and SNP rs3217992 was shown to be the SNP most significantly associated with AgP in multivariate analyses .…”

Section: Introductionmentioning

confidence: 99%

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Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

Schulz

Seitter

Werdan

et al. 2018

J of Periodontal Research

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CDKN2B - AS may indirectly regulate coronary artery disease-associated genes via targeting miR - 92a

Cited by 23 publications

References 40 publications

The long non-coding RNA SNHG14 inhibits cell proliferation and invasion and promotes apoptosis by sponging miR-92a-3p in glioma

The long non-coding RNA SNHG14 inhibits cell proliferation and invasion and promotes apoptosis by sponging miR-92a-3p in glioma

MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients

Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

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