cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2→q32.3

Yamamoto, Koh; Kobayashi, Hideki; Arai, Ayami; Miura, Osamu; Hirosawa, Shinsaku; Miyasaka, Nobuhiko

doi:10.1159/000134578

Cited by 37 publications

(18 citation statements)

References 12 publications

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“…moderate expression was found in testis consistent with the known IL-12 production and STAT-4 expression in this organ (29,30). Surprisingly, all founder lines displayed high luciferase activity in the small intestine but not in the colon, thus providing evidence for constitutive IL-12 p40 promoter activity in the former organ.…”

Section: Figuresupporting

confidence: 74%

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Becker¹,

Wirtz²,

Blessing³

et al. 2003

J. Clin. Invest.

197

190

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Section: Figuresupporting

confidence: 74%

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Becker¹,

Wirtz²,

Blessing³

et al. 2003

J. Clin. Invest.

197

190

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“…2B). No expression or induction of tissue-specific STAT4 (35) and STAT5 (28) was detected in the infected cells (data not shown). Together, these data demonstrated the induction/ presence of the JAK/STAT signal transduction pathway for type I and type II IFN signaling in Chlamydia-infected cells.…”

Section: Chlamydia Infection Induces Protein Expression Of the Jak/stmentioning

confidence: 93%

Up-Regulation of the JAK/STAT1 Signal Pathway during Chlamydia trachomatis Infection

Lad

Fukuda

et al. 2005

The Journal of Immunology

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Chlamydia trachomatis infection is the most common cause of sexually transmitted disease, leading to female pelvic inflammatory disease and infertility. The disease process has been linked to cellular response to this bacterial pathogen. This obligate intracellular pathogen infects macrophages, fibroblast cells, and epithelial and endothelial cells. We show in this study that infection of cervical epithelial cells, the primary target of Chlamydia trachomatis, leads to up-regulation and activation of the JAK/STAT signal pathway. Specifically, Chlamydia trachomatis infection of HeLa 229 cells selectively induces STAT1, STAT2, and IFN-stimulated transcription factor 3γ expression and promotes STAT1 activation. The up-regulation of STAT1 is dependent on bacterial replication, because treatment of infected cells with antibiotics prevents STAT1 up-regulation. By analysis of the gene transcriptional and cytokine expression profiles of host cells combined with the use of neutralizing Abs, we show that IFN-β production is critical for STAT1 induction in epithelial cells. Finally, we demonstrate that the host up-regulates STAT1 to restrict bacterial infection, because Chlamydia propagates more efficiently in STAT1-null or STAT1 knockdown cells, whereas Chlamydia growth is inhibited in cells with up-regulated STAT1 expression. This study demonstrates that the infected cells up-regulate the host innate antimicrobial response to chlamydial infection. It also highlights the importance of cellular response by nonimmune cells in host clearance of chlamydial infection.

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“…The STAT proteins are likely to have diverged from a single gene through several consecutive duplications into three genetic loci. Specifically, in humans, the STAT genes map to three chromosomal regions (Copeland et al 1995): STAT3, STAT5A, and STAT5B map to chromosome 17 (bands q11-1 to q22); STAT1 and STAT4 map to chromosome 2 (bands q12 to q33) (Yamamoto et al 1997, Haddad et al 1998; and STAT2 and STAT6 map to chromosome 12 (bands q13 to q14-1) (Leek et al 1997, Goureau et al 2001; Table 1). Differential splicing and proteolytic processing further increase the diversity of STAT function in cells (Haddad et al 1998, Ihle 2001.…”

Section: Structure and Function Of Stat5a/b Proteinsmentioning

confidence: 99%

Signal transducer and activator of transcription 5A/B in prostate and breast cancers

Tan

Nevalainen

2008

Endocrine Related Cancer

100

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Protein kinase signaling pathways, such as Janus kinase 2-Signal transducer and activator of transcription 5A/B (JAK2-STAT5A/B), are of significant interest in the search for new therapeutic strategies in both breast and prostate cancers. In prostate cancer, the components of the JAK2-STAT5A/B signaling pathway provide molecular targets for small-molecule inhibition of survival and growth signals of the cells. At the same time, new evidence suggests that the STAT5A/B signaling pathway is involved in the transition of organ-confined prostate cancer to hormonerefractory disease. This implies that the active JAK2-STAT5A/B signaling pathway potentially provides the means for pharmacological intervention of clinical prostate cancer progression. In addition, active STAT5A/B may serve as a prognostic marker for identification of those primary prostate cancers that are likely to progress to aggressive disease. In breast cancer, the role of STAT5A/B is more complex. STAT5A/B may have a dual role in the regulation of malignant mammary epithelium. Data accumulated from mouse models of breast cancer suggest that in early stages of breast cancer STAT5A/B may promote malignant transformation and enhance growth of the tumor. This is in contrast to established breast cancer, where STAT5A/B may mediate the critical cues for maintaining the differentiation of mammary epithelium. In addition, present data suggest that activation of STAT5A/B in breast cancer predicts favorable clinical outcome. The dual nature of STAT5A/B action in breast cancer makes the therapeutic use of STAT5 A/B more complex.

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cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2→q32.3

Cited by 37 publications

References 12 publications

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

Up-Regulation of the JAK/STAT1 Signal Pathway during Chlamydia trachomatis Infection

Signal transducer and activator of transcription 5A/B in prostate and breast cancers

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