Cdx2-expressing transgenic mice induce a gastric intestinal metaplasia with the increase of epithelial cell proliferation

Aberrant Expression of CDX2 in the Gastric Mucosa With and Without Intestinal Metaplasia: Effect of Eradication of Helicobacter pylori

“…We previously examined expression of CDX1/2 genes in the gastric specimens using reverse transcriptase‐polymerase chain reaction and reported that CDX1 expression was found only in gastric specimens with IM, whereas CDX2 expression was frequently found both in specimens with and without IM of patients infected with Helicobacter pylori [7]. As to the important role of Cdx2 in transdifferentiation of the gastric epithelial cells into IM, we reported that Cdx2 ‐expressing transgenic mice induced gastric IM with an increase of epithelial cell proliferation [8]. Thus, in the present study, we investigated expression of CDX2 protein in the gastric mucosa with and without IM immunohistochemically using monoclonal antibody to CDX2 protein.…”