Cefazolin Efficacy and Antibiotic Sensitivity Against Pathogenic Bacteria in Pediatric with Acute Upper Urinary Tract Infection

Fuke, Toshiya; Abe, Yoshifusa; Hoshino, Akihiro; Oto, Hideyasu; Sakai, Naho; Murayama, Jun-Ichiro; Yoshida, Koichiro; Itabashi, Kazuo

doi:10.11150/kansenshogakuzasshi.84.269

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Preliminarily, we reported the efficacy of cefazolin (CEZ) in children with febrile UTI. 4 The policy in our pediatric department is to administer CEZ as a first-line antibiotic to children who are hospitalized with their first febrile UTI. To validate this policy in this study, we retrospectively evaluated microbial susceptibility to CEZ and the efficacy of CEZ in terms of clinical manifestations and outcomes.…”

Section: Introductionmentioning

confidence: 99%

Validation of Cefazolin as Initial Antibiotic for First Upper Urinary Tract Infection in Children

Abe

Wakabayashi

Ogawa

et al. 2016

Global Pediatric Health

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To validate the policy of administering cefazolin (CEZ) as a first-line antibiotic to children who are hospitalized with their first febrile urinary tract infection (UTI), we evaluated microbial susceptibility to CEZ and the efficacy of CEZ. The 75 enrolled children with febrile UTI were initially treated with CEZ. Switching CEZ was not required in 84% of the patients. The median fever duration, prevalence of bacteremia, prevalence of UTI caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, and median duration of hospitalization were significantly higher in the CEZ-ineffective group. The risks of vesicoureteral reflux, indication of operation, and renal scarring are not increased, even when CEZ is ineffective as a first-line antibiotic. CEZ is effective in more than 80% of pediatric patients with their first febrile UTI, but it should be switched to appropriate antibiotics considering sepsis or the ESBL-producing Enterobacteriaceae pathogen, when fever does not improve within 72 hours.

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Section: Introductionmentioning

confidence: 99%

Validation of Cefazolin as Initial Antibiotic for First Upper Urinary Tract Infection in Children

Abe

Wakabayashi

Ogawa

et al. 2016

Global Pediatric Health

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“…Previously, it has been reported that 85–90% of upper UTIs in pediatric patients are caused by E. coli . In pediatric patients, cefazolin (50 mg/kg/day) results in sufficient favorable outcomes (Abe et al, 2016; Fuke et al, 2010). Cefazolin is excreted in urine at approximately 90% of the initial dose (Irie et al, 1999; Shimazu et al, 1980; Ueda et al, 1970).…”

Section: Introductionmentioning

confidence: 99%

Simple determination of urine cefazolin concentration in pediatric patients with urinary tract infections using high‐performance liquid chromatography

Abe

Momo

Abe

et al. 2022

Biomedical Chromatography

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Recently, global health concerns regarding increasing multidrug resistance have arisen. This study aimed to develop a simple, inexpensive and rapid high-performance liquid chromatography-ultraviolet (HPLC-UV) method for determining urinary concentrations of a first-generation cephem antibiotic in pediatric patients with urinary tract infections (UTIs). HPLC-UV was used to analyze urinary cefazolin concentrations at a detection wavelength of 254 nm. The assay used contained 10-fold diluted urine with an internal standard (cephapirin). The standard calibration curve for cefazolin was linear in the concentration range of 31.25-500 μg/ml (r 2 > 0.999). The retention times of cefazolin and the internal standard were 4.2 and 4.9 min, respectively. The within-and between-day coefficients of variation were in the concentration ranges 1.2-15.2 and 5.5-19.2%, respectively. The urinary cefazolin concentration of a pediatric patient with a UTI was 1,476.6 μg/ml, which was over 700-fold higher than the minimum inhibitory concentration of cefazolin (≤2 μg/ml).The developed method is applicable to the confirmation of appropriate use for UTI treatment as therapeutic drug monitoring of cefazolin. Therefore, the findings of this study may contribute to the appropriate use of antibiotics to prevent antimicrobial resistance in pediatric patients with UTIs.

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Cefazolin Efficacy and Antibiotic Sensitivity Against Pathogenic Bacteria in Pediatric with Acute Upper Urinary Tract Infection

Cited by 2 publications

References 5 publications

Validation of Cefazolin as Initial Antibiotic for First Upper Urinary Tract Infection in Children

Validation of Cefazolin as Initial Antibiotic for First Upper Urinary Tract Infection in Children

Simple determination of urine cefazolin concentration in pediatric patients with urinary tract infections using high‐performance liquid chromatography

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