2021
DOI: 10.1093/jac/dkab009
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Cefazolin versus ceftriaxone as definitive treatment forKlebsiella pneumoniaebacteraemia: a retrospective multicentre study in Singapore

Abstract: Background Ceftriaxone is the preferred treatment for bacteraemia caused by non-MDR (antibiotic-susceptible) Klebsiella pneumoniae. Excessive and widespread ceftriaxone use creates selection pressure for ESBLs. Cefazolin is an alternative, although there are theoretical concerns that SHV-1 β-lactamase in K. pneumoniae may inactivate cefazolin in an inoculum-dependent manner. Objectives In this retrospective study, we investig… Show more

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