Cefotetan versus cefoxitin as prophylaxis in hysterectomy

Orr, James W.; Varner, R. Edward; Kilgore, Larry C.; Holloway, Robert C.; McDiarmid, Mary

doi:10.1016/0002-9378(86)90498-9

Cited by 17 publications

(6 citation statements)

References 4 publications

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“…Single doses of cefotetan, ceftizoxime, or cefotaxime appear to be as effective as multiple doses of cefoxitin. [644][645][646][647][648][649]665 A second dose of antimicrobial is warranted when the procedure lasts three hours or longer or if blood loss exceeds 1500 mL. 9,654 Recommendation.…”

Section: Hysterectomy Proceduresmentioning

confidence: 99%

“…Studies comparing single doses of one antimicrobial with multidose regimens of a different antimicrobial have shown the two regimens to be equally effective in reducing the postoperative infection rate in women undergoing vaginal and abdominal hysterectomies. [635][636][637][638][639][640][641][642][643][645][646][647][648][649][650][655][656][657][658][659][660][661][662][663] The limited comparative trials involving single-dose cefazolin 637,654,655,664 or ampicillin-sulbactam 654,663 indicate that a single dose of antimicrobial is sufficient prophylaxis for SSIs for vaginal hysterectomy. Single doses of cefotetan, ceftizoxime, or cefotaxime appear to be as effective as multiple doses of cefoxitin.…”

Section: Hysterectomy Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

Clinical practice guidelines for antimicrobial prophylaxis in surgery

Bratzler

Dellinger

Olsen

et al. 2013

American Journal of Health-System Pharmacy

1,885

1,464

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Section: Hysterectomy Proceduresmentioning

confidence: 99%

Section: Hysterectomy Proceduresmentioning

confidence: 99%

Clinical practice guidelines for antimicrobial prophylaxis in surgery

Bratzler

Dellinger

Olsen

et al. 2013

American Journal of Health-System Pharmacy

1,885

1,464

View full text Add to dashboard Cite

“…Studies directly comparing different cephalosporins have found no significant differences in rates of infection in vaginal hysterectomy and have indicated that first-generation cephalosporins (primarily cefazolin) are equivalent to second-and third-generation agents [635][636][637][638][639][640][641][642][643][644]. In abdominal hysterectomy, no significant differences in the rates of serious infections were noted between second-and third-generation cephalosporin regimens [641,[645][646][647][648][649]. Few comparisons have been made between second-generation cephalosporins and cefazolin.…”

Section: Efficacymentioning

confidence: 99%

“…Duration. Studies comparing single doses of one antimicrobial with multidose regimens of a different antimicrobial have shown the two regimens to be equally effective in reducing the postoperative infection rate in women undergoing vaginal and abdominal hysterectomies [635][636][637][638][639][640][641][642][643][645][646][647][648][649][650][655][656][657][658][659][660][661][662][663]. The limited comparative trials involving singledose cefazolin [637,654,655,664] or ampicillin-sulbactam [654,663] indicate that a single dose of antimicrobial is sufficient prophylaxis for SSIs for vaginal hysterectomy.…”

Section: Efficacymentioning

confidence: 99%

Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery

Bratzler

Dellinger

Olsen

et al. 2013

Surgical Infections

1,203

1,225

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T hese guidelines were developed jointly by the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA). This work represents an update to the previously published ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery [1], as well as guidelines from IDSA and SIS [2,3]. The guidelines are intended to provide practitioners with a standardized approach to the rational, safe, and effective use of antimicrobial agents for the prevention of surgical site infections (SSIs) based on currently available clinical evidence and emerging issues. Prophylaxis refers to the prevention of an infection and can be characterized as primary prophylaxis, secondary prophylaxis, or eradication. Primary prophylaxis refers to the prevention of an initial infection. Secondary prophylaxis refers to the prevention of recurrence or reactivation of a preexisting infection. Eradication refers to the elimination of a colonized organism to prevent the development of an infection. These guidelines focus on primary perioperative prophylaxis. Guidelines development and use Members of ASHP, IDSA, SIS, and SHEA were appointed to serve on an expert panel established to ensure the validity, reliability, and utility of the revised guidelines. The work of the panel was facilitated by faculty of the

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“…Kontrovers hingegen sind die Ansichten noch bei der abdominalen Hysterektomie [2, 3,6,8,10,11,13,15,18]. In einer pharmakokinetischen Studie haben wir die Serum-und Gewebespiegel von Ciprofloxacin (Bay o9867) nach oraler und intravenöser Gabe in Uterus, Tube und Ovar bestimmt [5,7], Ciprofloxacin ist ein neues Derivat aus der Stoffgruppe der Chinolonc mit gesteigerter antibakterieller Aktivität im Vergleich zu analogen Substanzen aus der Gruppe der Gyrasehemmer wie Enoxacin, Norfloxacin, Ofloxacin und Pefloxacin [12,17,19].…”

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