Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study

Nathan, Nicolas; Borel, T.; Djibo, Ali; Evans, Deborah; Djibo, S.; Corty, JF; Gardembas, Martine; Alberti, KP; Pinoges, Loretxu; Guérin, Philippe J.; Legros, Dominique

doi:10.1016/s0140-6736(05)66792-x

Cited by 98 publications

(45 citation statements)

References 27 publications

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“…A shorter regimen is useful in developing countries, and several researchers have shown that 3 days of intravenous treatment with Penicillin G is effective (68). Treatment with single doses of both ceftriaxone and chloramphenicol resulted in a good outcome in a meningococcal meningitis epidemic in Niger, with a mortality of approximately 5% (69). Rifampin and ciprofloxacin showed significant efficacy in the eradication of N. meningitides, however, they are seldom used in current treatments -rather, they are used for chemoprophylaxis.…”

Section: Treatmentmentioning

confidence: 99%

Meningococcemia in Adults: A Review of the Literature

Takada

Fujiwara

Inoue³

et al. 2016

Intern. Med.

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We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. meningitidis, also called meningococcus, is a Gram-negative, aerobic, diplococcus bacterium. The various consequences of severe meningococcal sepsis include hypotension, disseminated intravascular coagulation (DIC), multiple organ failure, and osteonecrosis due to DIC. The gold standard for the identification of meningococcal infection is the bacteriologic isolation of N. meningitidis from body fluids such as blood, cerebrospinal fluid (CSF), synovial fluid, and pleural fluid. Blood, CSF, and skin biopsy cultures are used for diagnosis. Meningococcal infection is a medical emergency that requires antibiotic therapy and intensive supportive care. Management of the systemic circulation, respiration, and intracranial pressure is vital for improving the prognosis, which has dramatically improved since the wide availability of antibiotics. This review of the literature provides an overview of current concepts on meningococcemia due to N. meningitidis infection.

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Section: Treatmentmentioning

confidence: 99%

Meningococcemia in Adults: A Review of the Literature

Takada

Fujiwara

Inoue³

et al. 2016

Intern. Med.

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“…We analysed laboratory data from the CSF of 412 patients obtained during a randomized non-inferiority trial conducted during an epidemic of NmA in Niger in 2003 [15]. The sensitivity and specificity of the Gram stain for indicating presence or absence of intracellular diplococci versus a gold standard of culture and/or PCR was 66.3 and 96.4%, respectively.…”

Section: Gram Stainmentioning

confidence: 99%

Biological diagnosis of meningococcal meningitis in the African meningitis belt: Current epidemic strategy and new perspectives

Chanteau

Rose²,

Djibo

et al. 2007

Vaccine

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“…In that forest land, short-course treatment protocols and antibiotics with simple treatment schedules with the possibility of intramuscular injection for prior antibiotic therapy are necessary [3]. One daily dose of ceftriaxone (100 mg/Kg to a maximum of 4 g) administered intramuscularly seems to be a suitable option for the treatment of meningococcal disease and bacterial meningitis taking into account the circumstances found in Amazon inlands, its efficacy, and ease of use [27,28]. The occurrence of meningococcal disease in rural communities in the Amazon Region represents a public health challenge to decisions that are made regarding case ascertainment, outcome, and control of linked cases.…”

Section: Discussionmentioning

confidence: 99%

Neisseria meningitidis: a neglected cause of infectious haemorrhagic fever in the amazon rainforest

Barroso¹,

Silva²

2007

Braz J Infect Dis

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Neisseria meningitidis has not been seen as a significant cause of infectious haemorrhagic fever in the Amazon inlands; most reported cases are from the city of Manaus, the capital of the State of Amazonas. This picture is sustained by the lack of reliable microbiology laboratories, the perception of the health care workers, and the difficult to reach medical assistance; thus the number of confirmed cases is even lower with no reference of the strains phenotype. We report here the investigation of a case of suspected meningococcemia and his close contacts in a rural community in the Coari Lake, up the Amazon River.

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Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study

Cited by 98 publications

References 27 publications

Meningococcemia in Adults: A Review of the Literature

Meningococcemia in Adults: A Review of the Literature

Biological diagnosis of meningococcal meningitis in the African meningitis belt: Current epidemic strategy and new perspectives

Neisseria meningitidis: a neglected cause of infectious haemorrhagic fever in the amazon rainforest

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