Cefuroxime axetil (Ceftin�): a brief review

Leder, Rachel Deanne; Carson, Deborah Stier

doi:10.1002/(sici)1098-0997(1997)5:3<211::aid-idog3>3.0.co;2-v

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…In the pharmaceutical formulation studies, CDs have mostly been applied as complexing compounds to increase the water solubility and to improve the bioavailability and stability of poorly soluble drugs, for example, cephalosporins [ 24 ], including cefuroxime. Cefuroxime axetil (CA), an 1-acetoxyethyl ester of cefuroxime (prodrug), is a broad spectrum second-generation semisynthetic cephalosporin comprising a β-lactam ring [ 25 ], being effectively absorbed from the gastrointestinal tract due to its lipophilicity and subsequently de-esterified to cefuroxime [ 26 ]. The antibacterial activity of cefuroxime in vivo is the result of its capacity to bind target proteins located in the bacterial cell wall, which leads to the inhibition of cell wall synthesis, hence the bacteria lose their ability to divide and mature.…”

Section: Introductionmentioning

confidence: 99%

Molecular Structure of Cefuroxime Axetil Complexes with α-, β-, γ-, and 2-Hydroxypropyl-β-Cyclodextrins: Molecular Simulations and Raman Spectroscopic and Imaging Studies

Gieroba

Kalisz

Sroka-Bartnicka

et al. 2021

IJMS

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The formation of cefuroxime axetil+cyclodextrin (CA+CD) complexes increases the aqueous solubility of CA, improves its physico-chemical properties, and facilitates a biomembrane-mediated drug delivery process. In CD-based tablet formulations, it is crucial to investigate the molecular details of complexes in final pharmaceutical preparation. In this study, Raman spectroscopy and mapping were applied for the detection and identification of chemical groups involved in α-, β-, γ-, and 2-hydroxypropyl-β-CD (2-HP- β-CD)+CA complexation process. The experimental studies have been complemented by molecular dynamics-based investigations, providing additional molecular details of CA+CD interactions. It has been demonstrated that CA forms the guest–host type inclusion complexes with all studied CDs; however, the nature of the interactions is slightly different. It seems that both α- and β-CD interact with furanyl and methoxy moieties of CA, γ-CD forms a more diverse pattern of interactions with CA, which are not observed in other CDs, whereas 2HP-β-CD binds CA with the contribution of hydrogen bonding. Apart from supporting this interpretation of the experimental data, molecular dynamics simulations allowed for ordering the CA+CD binding affinities. The obtained results proved that the molecular details of the host–guest complexation can be successfully predicted from the combination of Raman spectroscopy and molecular modeling.

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Section: Introductionmentioning

confidence: 99%

Molecular Structure of Cefuroxime Axetil Complexes with α-, β-, γ-, and 2-Hydroxypropyl-β-Cyclodextrins: Molecular Simulations and Raman Spectroscopic and Imaging Studies

Gieroba

Kalisz

Sroka-Bartnicka

et al. 2021

IJMS

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An In vitro Study on impact of Vitamin-C on Cefuroxime mediated alterations in Bio-parameters associated with free Radical linked Lipid Decomposition

Ghosh,

Kumar Ghosh,

Devbhuti

et al. 2024

RJPT

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Background: Lipid peroxidation can be interpreting as an oxidative degeneration of lipids. It happens when a hydroxyl radical removes an electron from polyunsaturated fatty acids (PUFAs), which can react with oxygen and other polyunsaturated fatty acids to produceperoxyl radicals and hydroperoxides, thus promulgating the injury. So this repeat cycle of lipid peroxidation process can be responsible of cellular damage. Drug-induced lipid peroxidation is an important phenomenon found to be involved behind it’s certain hazardous side effects due to the generation toxic end products of such peroxidation like malonaldehyde (MA), hydroxynonenal (HNE), etc. Antioxidants play a crucial role in modifying such processes due to their free radical scavenging capability. Objective: Keeping in mind the matter, thisin vitroinvestigation was conducted using cefuroxime, a cephalosporin antibiotic as drug of choice and vitamin C as antioxidant taking liver tissue of goat as lipid source. Methods: The liver homogenate was divided in certain experimental groups that were treated with cefuroxime and ascorbic acid for specific time periods. The level of MA and HNE in the samples was estimated and compared with control. Result: The result showed that Cefuroxime has lipid peroxidation induction capability that was counteracted by ascorbic acid. Conclusion: Thus cefuroxime-induced, peroxidation associated, toxicities may be managed well upon co-administration with the antioxidant vitamin C.

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Cefuroxime axetil (Ceftin�): a brief review

Cited by 2 publications

References 13 publications

Molecular Structure of Cefuroxime Axetil Complexes with α-, β-, γ-, and 2-Hydroxypropyl-β-Cyclodextrins: Molecular Simulations and Raman Spectroscopic and Imaging Studies

Molecular Structure of Cefuroxime Axetil Complexes with α-, β-, γ-, and 2-Hydroxypropyl-β-Cyclodextrins: Molecular Simulations and Raman Spectroscopic and Imaging Studies

An In vitro Study on impact of Vitamin-C on Cefuroxime mediated alterations in Bio-parameters associated with free Radical linked Lipid Decomposition

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