Celiac Disease in Two Different Population Groups of South Tirol

Pittschieler, K; Reissigl, H; Mengarda, G

doi:10.1097/00005176-198805000-00014

Cited by 13 publications

(10 citation statements)

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“…One of the aims of this study was to compare our previous data on ethnic differences among gluten intolerance in the Region of South Tyrol from a large population screening (9). In this study a CD prevalence of 163/100000 in the Italian and 216/lOOOOO in the German-speaking ethnic group was recorded.…”

Section: Discussionmentioning

confidence: 99%

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Coeliac disease: screened by a new strategy

Pittschieler

Ladinser

1996

Acta Paediatrica

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The incidence of coeltac disease is different throughout Europe. The aim of our study was to investigate its true prevalence using antigliadin and endomysial antibodies in 4615 healthy adults within two different population groups in Northern Italy: 140 were positive for antigliadin antibodies (AGA), 111 only for AGA IgG, 17 for AGA IgA and 12 for IgG and IgA. Of those positive for AGA, nine had an abnormal small‐intestinal mucosa and were positive for endomysium antibodies (EmA) using the umbilical cord test, a novel methodology. The prevalence, 163/100 000 in the Italian group and 216/ 100 000 in the German group, is much higher that what was assumed. The positive predictive value of the EmA, confirmed by biopsy, is 100%, that of AGA IgG 2%, of AGA IgA 12% and of the combined AGA IgA and IgG 33%. AGA positive but EmA negative patients displayed normal histological features and distributions of α/β and γ/δ T‐cell receptors on intraepithelial lymphocytes. We can therefore conclude that antigliadin antibodies are not an ideal tool for screening purposes; the umbilical cord EmA test is superior owing to its optimal sensitivity, specificity, high positive predictive value and low cost.

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Section: Discussionmentioning

confidence: 99%

“…In a study published a few years ago, we described in South Tyrol, an alpine region in Northern Italy, different prevalences in two ethnic groups, Italian and German, living together under similar environmental condition. (9). This region is surrounded by German-speaking areas with a high prevalence of CD, i.e.…”

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confidence: 99%

Coeliac disease: screened by a new strategy

Pittschieler

Ladinser

1996

Acta Paediatrica

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“…Significant inter-country differences are apparent. Considering various time periods together, incidence rates for both sexes combined ranged from 0.9 to 12.9/ 100 000/year for all ages combined, 20-26 0-3.7/1000 live births for children [15][16][17][18][19][20][21]24,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] and 1.27-39/100 000/year for adults. 35,[45][46][47] Again considering various time periods together, prevalence rates for both sexes ranged from 8.1 to 204/100 000 for all ages, 26, 48-51 4.7-250/100 000 for children 16,19,26,48,52,53 and 45.9-550/100 000 for adults.…”

Section: Incidence and Prevalence Of Clinically Diagnosed CD (Tables mentioning

confidence: 99%

Systematic review: worldwide variation in the frequency of coeliac disease and changes over time

Kang

Green

et al. 2013

Aliment Pharmacol Ther

231

182

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Summary Background Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub‐Saharan Africa. Aim To assess geographical differences and time trends in the frequency of CD. Methods Medline and Embase searches were conducted on 10 November 2012, from 1946 and 1980 respectively, using the key words: coeliac disease or celiac disease + prevalence or incidence or frequency. Results There were significant intra‐ and inter‐country differences in the prevalence and incidence of CD. Only 24 ethnic Chinese and Japanese patients have been reported in the English literature. Of CD‐associated HLA DQ antigens, DQ2 occurs in 5–10% of Chinese and sub‐Saharan Africans, compared to 5–20% in Western Europe. DQ8 occurs in 5–10% of English, Tunisians and Iranians, but in <5% of Eastern Europeans, Americans and Asians. The prevalence and incidence of both clinically and serologically diagnosed CD increased in recent years. These geographical and temporal differences seem genuine, although variable indices of suspicion and availability of diagnostic facilities are confounding factors. Conclusions Coeliac disease is increasing in frequency, with significant geographical differences. Although few cases have been described to date in the Orient and Sub‐Saharan Africa, there is a significant prevalence of HLA DQ2 and wheat consumption is of the same order as that in Western Europe. CD may therefore become more common in the future in these countries.

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“…Recent studies in childhood coeliac disease (CCD) have disclosed highly varying incidence rates by birth (between 0.09 and 2.93: lOOO), even in closely related geographic areas (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Differing changes in incidence rates of CCD have also been reported since the second half of the 1970s: decreasing (3,6,(14)(15)(16)(17), increasing (5,11,12), or unchanged (7,9,13).…”

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confidence: 99%