Celiac Disease Patients Presenting With Anemia Have More Severe Disease Than Those Presenting With Diarrhea

Daya, Hussein Abu; Lebwohl, Benjamin; Lewis, Suzanne K.; Green, Peter H.

doi:10.1016/j.cgh.2013.05.030

Cited by 66 publications

(41 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean hemoglobin and median ferritin levels in our study were significantly lower in patients with severe villous atrophy compared to those with mild atrophy. Recent studies have also established that patients with anemia have more severe villous atrophy, with higher levels of inflammatory markers and tTG antibodies than in patients with diarrhea …”

Section: Discussionmentioning

confidence: 99%

Anemia in celiac disease is multifactorial in etiology: A prospective study from India

et al. 2018

View full text Add to dashboard Cite

Background and AimsAnemia is one of the most common extraintestinal manifestations of celiac disease (CD), with iron deficiency anemia (IDA) being the predominant cause. However, anemia in CD can have varied etiologies, including mixed nutritional deficiency. We aimed to study the prevalence and etiology of anemia in CD in a north Indian population.MethodsIn this prospective observational study, consecutive patients with documented CD between January 2012 and December 2013 were included, and all patients underwent detailed clinical assessment; hematological investigations including iron profile, serum folate, and vitamin B12 levels; and esophageoduodenoscopy with duodenal biopsies for histopathological examination. Prevalence of anemia and different deficiencies were calculated, and a correlation between hematological parameters and histological findings was found.ResultsOf the 103 patients studied, anemia was detected in 96 patients, giving a prevalence of 93.2% with a baseline hemoglobin of 8.94 ± 2.54 g/dL. Overall, iron deficiency was seen in 84 (81.5%) patients, followed by vitamin B12 deficiency in 14 (13.6%) and folate deficiency in 11 (10.7%) patients; 17 (16.5%) patients had anemia due to mixed nutritional deficiencies, and 4 (3.9%) patients had anemia of chronic disease. The mean hemoglobin and median ferritin levels were significantly lower in patients with severe villous atrophy compared to those with mild atrophy.ConclusionAnemia in patients with CD is multifactorial. Even though iron deficiency is the most common cause, other nutrient deficiencies should always be explored.

show abstract

Section: Discussionmentioning

confidence: 99%

Anemia in celiac disease is multifactorial in etiology: A prospective study from India

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, our recent study of patients who presented with diarrhea compared to those who presented with anemia suggested that those with anemia had more severe disease. The anemia group had higher ESR, serum tissue transglutaminase levels, more severe degrees of villous atrophy and worse bone disease [18]. …”

Section: Introductionmentioning

confidence: 99%

Clinical Manifestations of Celiac Disease

Green¹,

Krishnareddy²,

Lebwohl³

2015

Dig Dis

Self Cite

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-based condition affecting multiple organ systems. Clinical manifestations are manifold in form and number due to the multisystem nature of CD. There has been a progressive change in the clinical manifestations over the recent decades with fewer patients, both adults and children, presenting with a diarrheal, classical form. This, in children, is seen in only the youngest, while growth issues, screening at-risk groups and recurrent abdominal pain are the most common modes of presentation among children. Among adults, diarrhea is the most common presentation followed by anemia. Screening at-risk groups, metabolic bone disease and incidental recognition at endoscopy performed for reflux are the other main modes of presentation. The bulk of those with CD remain undiagnosed. The symptoms are often common, and increased medical education should lead to greater awareness in the medical community and an increased rate of diagnosis.

show abstract

“…The clinical utility of such VAs may be evident in patients requiring iron and calcium supplementation to simultaneously restore iron deficiency and prevent osteoporosis (Abu Daya et al . ; Krupa‐Kozak ).…”

Section: Discussionmentioning

confidence: 99%

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng

Chen

Lai

et al. 2015

Animal Science Journal

View full text Add to dashboard Cite

For this study, we aimed to assess the dose-response antiosteoporotic effects of the middle section of velvet antlers (VAs) from sika deers (Cervus nippon) fed with different types of fodders. VAs prepared from farmed sika deers fed with feed mixtures containing sorghum distillery residue (VA-SDR) or without SDR (SDR replaced with hay, VA-Hay) were divided into upper (VAU), middle (VAM) and basal (VAB) sections. The chemical constituents of the middle sections obtained from each VA type were compared, and their antiosteoporotic activities were evaluated using rats with ovaries removed surgically (ovariectomy, OVX). The VA-Hay exhibited markedly increased iron and cysteine levels, whereas the VA-SDR exhibited markedly increased level of alcoholic extract and testosterone. Both VA-Hay- and VA-SDR-treated rats exhibited increased femur strength compared with the control group. However, VA-SDR exhibited greater bone-strengthening effects than did VA-Hay. The serum osteocalcin and estradiol levels were significantly moderated in the VA-Hay group alone. These results suggest that VA-SDR and VA-Hay prevent the loss of bone strength, and preserve trabecular architecture connectivity in an estrogen-deficient state. However, differences in the chemical compositions of different forages may be responsible for the varying antiosteoporotic mechanisms observed. Thus, the addition of SDR in deer forage may enhance antiosteoporosis activity in VAs, and confer considerable economic and ecological benefits.

show abstract

Celiac Disease Patients Presenting With Anemia Have More Severe Disease Than Those Presenting With Diarrhea

Cited by 66 publications

References 39 publications

Anemia in celiac disease is multifactorial in etiology: A prospective study from India

Anemia in celiac disease is multifactorial in etiology: A prospective study from India

Clinical Manifestations of Celiac Disease

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Contact Info

Product

Resources

About