Cell adhesion to borate glasses by colloidal probe microscopy

Application of the Johnson–Kendall–Roberts model in AFM-based mechanical measurements on cells and gel.

“…However, in most research the capabilities of force spectroscopy are not fully used. Retraction (unloading) curves containing information about adhesion and tether extraction are rarely evaluated [16,17], or only the adhesion region is analyzed [18,19]. Furthermore, the hysteresis observed in approach and retraction curves and attributed to the energy dissipation during indentation can be used for the estimation of cell viscoelastic properties (e.g.…”