Cell‐autonomous astrocytopathy in Alzheimer's disease

A unified model of dementias and age‐related neurodegeneration

“…One leading model used by many pharmaceutical firms, for example, has been that AD is caused by A deposition and other markers of AD are secondary, implying that an intervention tar- In AD, there has been a growing, if informal, consensus 27 that a more fundamental upstream mechanism underlies the pathognomonic findings. The mechanism is often attributed to glial cell dysfunction, [28][29][30][31][32][33] although there is no agreement on the glial cell changes that result in downstream findings. [34][35][36][37][38] This type of model ( Figure 3) can be represented by a single fundamental upstream mechanism causing multiple downstream findings, including amyloid plaque, tau tangles, mitochondrial dysfunction, 39 lipid processing, 40 TDP-43 proteinopathy, 41 immune function, and synaptic loss.…”