Cell-based neurorestorative therapy for postpoliomyelitis syndrome: a case report

Hao, Xi Shan; Chen, Di

doi:10.2147/jn.s98584

Cited by 5 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of clinical studies concerning cell therapies with a positive outcome have led to the suggestion that combination cell therapies and/or certain transplantation approaches with rehabilitation can be more effective 107 , 123 , 128 – 130 , 136 , 138 – …”

Section: Provisionsmentioning

confidence: 99%

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

et al. 2018

Self Cite

View full text Add to dashboard Cite

Cell therapy has been shown to be a key clinical therapeutic option for central nervous system diseases or damage. Standardization of clinical cell therapy procedures is an important task for professional associations devoted to cell therapy. The Chinese Branch of the International Association of Neurorestoratology (IANR) completed the first set of guidelines governing the clinical application of neurorestoration in 2011. The IANR and the Chinese Association of Neurorestoratology (CANR) collaborated to propose the current version “Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)”. The IANR council board members and CANR committee members approved this proposal on September 1, 2016, and recommend it to clinical practitioners of cellular therapy. These guidelines include items of cell type nomenclature, cell quality control, minimal suggested cell doses, patient-informed consent, indications for undergoing cell therapy, contraindications for undergoing cell therapy, documentation of procedure and therapy, safety evaluation, efficacy evaluation, policy of repeated treatments, do not charge patients for unproven therapies, basic principles of cell therapy, and publishing responsibility.

show abstract

Section: Provisionsmentioning

confidence: 99%

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…The presence of active neurogenesis in the adult human nervous system, except for the olfactory neuroepithelium, is still controversial. [52][53][54], multiple system atrophy (MSA) [55], postpoliomyelitis syndrome [56], SCI [57][58][59][60], and sciatic nerve injury [61].…”

Section: The Basic Characterization Of the Olfactory Neuroepitheliummentioning

confidence: 99%

Why is olfactory neuroepithelium?

Huang¹

2021

Journal of Neurorestoratology

View full text Add to dashboard Cite

Currently, most cellular therapeutic effects for nervous diseases cannot be proven in a multicenter, randomized, double-blind placebo-control clinical trials, except for a few kinds of cells such as olfactory ensheathing cells. These cells show significant improvements in functional recovery and quality of life for patients with chronic ischemic stroke. Also, olfactory neuron transplantation has promising neurorestorative effects on patients with vascular dementia. Human olfactory neuroepithelium can spontaneously and sustainably regenerate or produce new olfactory neurons and glial cell types for decades or a lifetime. The neurorestorative mechanisms of olfactory ensheathing cells are well known; however, little is known about the neurorestorative mechanisms of olfactory neurons. Therefore, I hypothesize that the neurorestorative mechanisms of olfactory neurons after transplantation: (1) can well migrate where they are needed and become local functional neurons, as they need to compensate or replace; (2) must be regulated by some special molecular factors to elongate their axons, modulate or direct synapses to correctly recognize and connect the target cells, and integrate functions. Based on olfactory neuroepithelium cells displaying the special characterization, neurorestorative mechanisms, clinical therapeutic achievements, and hypotheses of effective mechanisms, they (olfactory ensheathing cells and olfactory neurons) may be the most efficient instruments of neurorestoration.

show abstract

“…Some case reports also showed benefits of cell therapy for patients with postpoliomyelitis syndrome 41 and primary torsion dystonia. 42…”

Section: New Clinical Evidence For Neurorestorative Strategies Cell Tmentioning

confidence: 99%

2016 yearbook of neurorestoratology

Huang¹,

Mao²,

Feng³

et al. 2017

View full text Add to dashboard Cite

Neurorestoratology, a new interdisciplinary field, has gradually become a popular clinical discipline. Physicians and scientists in the neurorestoration field have discovered new pathogeneses of nervous system diseases and damage, explored new neurorestorative mechanisms, and obtained improving neurorestorative effects in clinical trials (or therapies). This paper summarizes the major progress achieved over the past year.

show abstract

Cell-based neurorestorative therapy for postpoliomyelitis syndrome: a case report

Cited by 5 publications

References 27 publications

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Clinical Cell Therapy Guidelines for Neurorestoration (IANR/CANR 2017)

Why is olfactory neuroepithelium?

2016 yearbook of neurorestoratology

Contact Info

Product

Resources

About