Cell biology in China: Focusing on the lysosome

Yang, Chonglin; Wang, Xiaochen

doi:10.1111/tra.12483

Cited by 13 publications

(6 citation statements)

References 93 publications

(126 reference statements)

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“…Lysosomes are the major digestive organelles that degrade both extra-and intracellular materials generated by endocytosis, phagocytosis, and autophagy; thus, they play important roles in many physiological processes such as the immune response, plasma membrane repair, bone resorption, and cell death (Luzio et al, 2007;Saftig and Klumperman, 2009;Xu and Ren, 2015;Yang and Wang, 2017). Lysosomes also serve as signaling hubs that sense cellular energy and amino acid levels and mediate signal transduction (Efeyan et al, 2015;Ferguson, 2015;Settembre et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

Yin

Jian

et al. 2020

Journal of Cell Biology

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Lysosomes are degradation and signaling organelles that adapt their biogenesis to meet many different cellular demands; however, it is unknown how lysosomes change their numbers for cell division. Here, we report that the cyclin-dependent kinases CDK4/6 regulate lysosome biogenesis during the cell cycle. Chemical or genetic inactivation of CDK4/6 increases lysosomal numbers by activating the lysosome and autophagy transcription factors TFEB and TFE3. CDK4/6 interact with and phosphorylate TFEB/TFE3 in the nucleus, thereby inactivating them by promoting their shuttling to the cytoplasm. During the cell cycle, lysosome numbers increase in S and G2/M phases when cyclin D turnover diminishes CDK4/6 activity. These findings not only uncover the molecular events that direct the nuclear export of TFEB/TFE3, but also suggest a mechanism that controls lysosome biogenesis in the cell cycle. CDK4/6 inhibitors promote autophagy and lysosome-dependent degradation, which has important implications for the therapy of cancer and lysosome-related disorders.

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Section: Introductionmentioning

confidence: 99%

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

Yin

Jian

et al. 2020

Journal of Cell Biology

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“…Lysosomal pathways are among the immunological pathways enriched for differentially downregulated genes in the SC-SE group. Lysosomes maintain cellular homeostasis, act as signaling centers, integrate metabolism with cellular clearance, and are involved in many fundamental cellular processes such as plasma membrane repair, immune response, and cell death (Yang and Wang, 2017). The above results indicate that the immune genes and pathways that may be down-regulated after Vibrio infection during larvae period are not consistent with those of adults.…”

Section: A B Figurementioning

confidence: 89%

The transcriptome of Litopenaeus vannamei in zoea larvae and adults infected by Vibrio parahaemolyticus

Nanxiong

Jin

Chen³

et al. 2023

Front. Mar. Sci.

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IntroductionThe rapid development of the Litopenaeus vannamei industry largely depends on the acquisition of high-quality larvae. Shrimp larval development is a unique metamorphic process that results in mortality due to disease vulnerability. Currently, studies on innate immunity in shrimp are mainly focused on the adult stage, but little has been done on innate immunity in larvae.MethodsIn this study, utilizing a high-throughput Illumina sequencing approach, we compare the transcriptome of L. vannamei Zoea larvae and adults infected by Vibrio parahaemolyticus.ResultsA total of 487,887,650 high quality reads were obtained, assembled, and aggregated into 23,802 genes, among which 3315 were identified as differentially expressed genes. Then GO term enrichment analysis, KEGG pathway enrichment analysis and functional gene analysis were performed. We found that pathways that are involved in the innate immune response, such as mTOR signaling pathway, MAPK signaling pathway, and Notch signaling pathway, were more enriched in the Zoea stage compared to the adult stage, suggesting that innate immunity against Vibrio vulnificus may exist during the Zoea larvae stage.Discussionwere more enriched in the Zoea stage compared to the adult stage, suggesting that innate immunity against Vibrio vulnificus may exist during the Zoea larvae stage. These findings will provide useful information for the study of innate immunity in shrimp larvae.

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“…The nematode C. elegans , with its short life cycle, well-characterized genome, and powerful genetic tools, provides an excellent and unique system for genetic and cell biological dissection of lysosomal homeostasis and functions (Gan et al 2019 ; Li et al 2016a ; Liu et al 2012 , 2016 ; Xu et al 2014 ; Yang and Wang 2017 , 2021 ). Moreover, the requirement for lysosomes in animal development and aging is reflected in a straightforward way in C. elegans .…”

Section: Caenorhabditis Elegans As a Model To Study Lysosomesmentioning

confidence: 99%

Exploring lysosomal biology: current approaches and methods

Yin,

Yang

2024

swwlxb

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Lysosomes are the degradation centers and signaling hubs in the cell. Lysosomes undergo adaptation to maintain cell homeostasis in response to a wide variety of cues. Dysfunction of lysosomes leads to aging and severe diseases including lysosomal storage diseases (LSDs), neurodegenerative disorders, and cancer. To understand the complexity of lysosome biology, many research approaches and tools have been developed to investigate lysosomal functions and regulatory mechanisms in diverse experimental systems. This review summarizes the current approaches and tools adopted for studying lysosomes, and aims to provide a methodological overview of lysosomal research and related fields.

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Cell biology in China: Focusing on the lysosome

Cited by 13 publications

References 93 publications

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

CDK4/6 regulate lysosome biogenesis through TFEB/TFE3

The transcriptome of Litopenaeus vannamei in zoea larvae and adults infected by Vibrio parahaemolyticus

Exploring lysosomal biology: current approaches and methods

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