Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell

Martinez, Michael A.Q.; Zhao, Chris Z.; Moore, Frances E.Q.; Yee, Callista; Zhang, Wan; Shen, Kang; Martin, Benjamin L.; Matus, David Q.

doi:10.1016/j.diff.2024.100765

Differentiation

2024

DOI: 10.1016/j.diff.2024.100765

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Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell

Michael A.Q. Martinez,

Chris Z. Zhao,

Frances E.Q. Moore

et al.

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2024

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The proliferation and differentiation programs are only partially coupled duringC. elegansintestine development

Dieng,

Michaux,

Pacquelet

2024

Preprint

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Cell proliferation and differentiation are essential processes underlying multicellular organism development. Cell proliferation arrest usually precedes terminal differentiation, suggesting that these two processes may be coordinated. Here we took advantage of the very stereotyped development of theC. elegansintestine to address whether the control of the proliferation and differentiation programs are systematically coupled. We show that retarding cell cycle arrest leads to a delay in the recruitment of some, but not all, brush border components. Reciprocally, we find that cell cycle arrest relies on the differentiation factors ELT-2 and ELT-7 only in posterior intestinal cells. The occurrence of supernumerary divisions in the absence of ELT-2 and ELT-7 is associated with changes in the expression pattern of the cell cycle regulators CKI-1 and cyclin B1. Our work thus demonstrates the existence of reciprocal interactions between cell proliferation and cell differentiation. It nevertheless also shows that these two processes are only partially coupled, suggesting the existence of additional mechanisms ensuring their temporal control.

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The proliferation and differentiation programs are only partially coupled duringC. elegansintestine development

Dieng,

Michaux,

Pacquelet

2024

Preprint

View full text Add to dashboard Cite

show abstract

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Cell cycle perturbation uncouples mitotic progression and invasive behavior in a post-mitotic cell

Cited by 1 publication

References 70 publications

The proliferation and differentiation programs are only partially coupled duringC. elegansintestine development

The proliferation and differentiation programs are only partially coupled duringC. elegansintestine development

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