Cell Cycle Withdrawal Limit the Regenerative Potential of Neonatal Cardiomyocytes

Yan, Han; Rao, Xiyun; Wang, Rui; Zhu, Shichao; Liu, Renjing; Zheng, Xiangjian

doi:10.1007/s13239-021-00551-w

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…325 Following heart damage, this lack of proliferation leads to pathological healing processes and fibrotic scarring. [326][327][328] The majority of studies on stem cell therapies has demonstrated enhanced cardiac function and vascularization along with decreased infarct size despite the transplanted cells dying quickly in the damaged myocardium. This suggests that paracrine mechanisms play the most significant role in cardiac healing.…”

Section: Myocardial Infarctions and Injurymentioning

confidence: 99%

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Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Miron,

Estrin,

Sculean

et al. 2024

Periodontology 2000

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Exosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. Today exosomes have been applied in numerous contexts including neurodegenerative disorders (Alzheimer's disease, central nervous system, depression, multiple sclerosis, Parkinson's disease, post‐traumatic stress disorders, traumatic brain injury, peripheral nerve injury), damaged organs (heart, kidney, liver, stroke, myocardial infarctions, myocardial infarctions, ovaries), degenerative processes (atherosclerosis, diabetes, hematology disorders, musculoskeletal degeneration, osteoradionecrosis, respiratory disease), infectious diseases (COVID‐19, hepatitis), regenerative procedures (antiaging, bone regeneration, cartilage/joint regeneration, osteoarthritis, cutaneous wounds, dental regeneration, dermatology/skin regeneration, erectile dysfunction, hair regrowth, intervertebral disc repair, spinal cord injury, vascular regeneration), and cancer therapy (breast, colorectal, gastric cancer and osteosarcomas), immune function (allergy, autoimmune disorders, immune regulation, inflammatory diseases, lupus, rheumatoid arthritis). This scoping review is a first of its kind aimed at summarizing the extensive regenerative potential of exosomes over a broad range of diseases and disorders.

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Section: Myocardial Infarctions and Injurymentioning

confidence: 99%

“…The persistent prevalence of heart failure‐related illness and mortality necessitates the focused efforts by researchers globally to develop effective treatments for cardiac restoration 325 . Following heart damage, this lack of proliferation leads to pathological healing processes and fibrotic scarring 326–328 …”

Section: Treatment Of Damaged Organsmentioning

confidence: 99%

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Miron,

Estrin,

Sculean

et al. 2024

Periodontology 2000

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show abstract

“…After birth, mammalian cardiomyocytes undergo a number of maturation changes associated with increased cardiac function and output, including hypertrophic growth [22], cell cycle withdrawal [23], myosin isoform conversion [24], and mitochondrial maturation [25,26]. Piquereau et al revealed the link between the maturation of energy pathways and cellular structure within cardiac myocytes during the development of the mouse heart from birth to adulthood [27].…”

Section: Postnatal Stagementioning

confidence: 99%

Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

Huang

Zhou

2023

Biomedicines

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Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for various physiological activities of the cell. Cardiomyocytes have a high density of mitochondria and mitochondrial damage is present in a variety of cardiovascular diseases. In this paper, we describe mitochondrial damage in mitochondrial cardiomyopathy, congenital heart disease, coronary heart disease, myocardial ischemia–reperfusion injury, heart failure, and drug-induced cardiotoxicity, in the context of the key roles of mitochondria in cardiac development and homeostasis. Finally, we discuss the main current therapeutic strategies aimed at alleviating mitochondrial impairment-related cardiac dysfunction, including pharmacological strategies, gene therapy, mitochondrial replacement therapy, and mitochondrial transplantation. It is hoped that this will provide new ideas for the treatment of cardiovascular diseases.

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“…Using this technique on P4 mice, it was shown that although cardiomyocyte proliferation increased 21 days post MI, cardiac hypertrophy was also observed 60 days after injury. This emphasizes how narrow the regenerative window is to achieve complete regeneration in mammals ( 25 ).…”

Section: Modelsmentioning

confidence: 99%

The multifaceted nature of endogenous cardiac regeneration

Rolland

Jopling

2023

Front. Cardiovasc. Med.

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Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury. In particular, analysis of cardiac regeneration in zebrafish and neonatal mice has uncovered numerous mechanisms involved in the regenerative process. It is now apparent that cardiac regeneration is not simply achieved by inducing cardiomyocytes to proliferate but requires a multifaceted response involving numerous different cell types, signaling pathways and mechanisms which must all work in harmony in order for regeneration to occur. In this review we will endeavor to highlight a variety of processes that have been identifed as being essential for cardiac regeneration.

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Cell Cycle Withdrawal Limit the Regenerative Potential of Neonatal Cardiomyocytes

Cited by 4 publications

References 20 publications

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Understanding exosomes: Part 2—Emerging leaders in regenerative medicine

Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies

The multifaceted nature of endogenous cardiac regeneration

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