Cell Death: a Molecular Perspective

Zia, Qamar; Azhar, Asim; Hassan, Nazia; Jain, Pooja; Singh, Manvi; Mirza, Mohd Aamir; Ali, Asgar; Parveen, Shaista; Hasan, Shahnaz; Alothaim, Abdulaziz S.; Jamal, Azfar

doi:10.1007/s40610-021-00146-3

Cited by 2 publications

(2 citation statements)

References 215 publications

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“…In contrast, necrotic cells experience uncontrolled, accidental cell death, typically resulting from physical injury, infection, or severe cellular stress. The key distinction lies in the orderly and organized nature of Apoptosis versus the chaotic and detrimental process of necrosis [52].…”

Section: Apoptotic and Necrotic Cellsmentioning

confidence: 99%

A comparative study of antioxidative, antimicrobial, and anticancer activities of ginger and lemon peel extracts

Samir,

El-Kholany,

Bakr

et al. 2024

Delta University Scientific Journal

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Owing to their great quantity of various phytochemicals, ginger, and lemon peel extracts exhibit potent antioxidant, antimicrobial, and anticancer properties. The present study was designed to investigate the phytochemical composition of ginger and lemon peel aqueous and ethanolic extracts, their potential antimicrobial activity, and anticancer properties. Ginger peel powder possesses the highest phytochemical content compared to lemon peels. Furthermore, the maximum phenolic and flavonoid contents of ginger were extracted in ethanolic extracts, which were documented as 20.65 mg GAE/g and 12.96 mg QC/g compared to lemon peel extracts. Additionally, ethanolic and aqueous ginger peel extracts exhibited superior antioxidant activity (96.91 and 95.77%, respectively) compared to lemon peel extract. HPLC fractionation further revealed the diverse phenolic and flavonoid compounds present in both peels, with ethanolic extracts consistently outperforming their aqueous ones. The ethanolic extracts of both ginger and lemon peels exhibit a higher degree of antimicrobial activity compared to their aqueous extract. Notably, the ethanolic extract of ginger peels demonstrates remarkable inhibition zones, particularly against gram-positive bacteria and gram-negative bacteria. On the other hand, ethanolic extracts of both peels exhibited potent cytotoxic effects against liver and colon carcinoma cells, with ethanolic extract of ginger peel showing superior anticancer potential with IC50 (4.7 and 5.2 µg/ml, respectively). Apoptotic and necrotic cell analyses underscored the ability of ginger peel ethanolic extract to induce a higher level of cancer cell apoptosis while minimizing necrosis. Therefore, our study lies in the distinct phytochemical profile of ginger and lemon peel extracts, emphasizing the higher phenolic and flavonoid contents in ethanolic extracts and their effect as antimicrobial and anticancer activity.

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Section: Apoptotic and Necrotic Cellsmentioning

confidence: 99%

A comparative study of antioxidative, antimicrobial, and anticancer activities of ginger and lemon peel extracts

Samir,

El-Kholany,

Bakr

et al. 2024

Delta University Scientific Journal

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“…The occurrence of a necrotic morphotype is observed in the context of ferroptosis, a form of cell death characterized by various mitochondrial changes such as shrinkage, an electron-dense ultrastructure, diminished or absent cristae, and ruptured OMM. Importantly, this process is not reliant on caspases, necrosome components, or cyclophilin D (CYPD), and operates independent of the molecular machinery involved in autophagy [143,144]. In the context of ferroptosis, it has been seen that mitochondria undergo a reduction in size as a result of weakened cristae and the occurrence of collapsed and ruptured membranes.…”

Section: Ferroptosis: Iron-dependent Cell Deathmentioning

confidence: 99%

Types of Cell Death from a Molecular Perspective

Hajibabaie,

Abedpoor,

Mohamadynejad

2023

Biology

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The former conventional belief was that cell death resulted from either apoptosis or necrosis; however, in recent years, different pathways through which a cell can undergo cell death have been discovered. Various types of cell death are distinguished by specific morphological alterations in the cell’s structure, coupled with numerous biological activation processes. Various diseases, such as cancers, can occur due to the accumulation of damaged cells in the body caused by the dysregulation and failure of cell death. Thus, comprehending these cell death pathways is crucial for formulating effective therapeutic strategies. We focused on providing a comprehensive overview of the existing literature pertaining to various forms of cell death, encompassing apoptosis, anoikis, pyroptosis, NETosis, ferroptosis, autophagy, entosis, methuosis, paraptosis, mitoptosis, parthanatos, necroptosis, and necrosis.

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Cell Death: a Molecular Perspective

Cited by 2 publications

References 215 publications

A comparative study of antioxidative, antimicrobial, and anticancer activities of ginger and lemon peel extracts

A comparative study of antioxidative, antimicrobial, and anticancer activities of ginger and lemon peel extracts

Types of Cell Death from a Molecular Perspective

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