Cell death along the embryo midline regulates left–right sidedness

Kelly, Kristine; Wei, Yan; Matsukawa, Takashi

doi:10.1002/dvdy.10098

Cited by 26 publications

(36 citation statements)

References 42 publications

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“…The embryonic midline is a hypothetical line until Hensen's node and the primitive groove form. To date, the primitive streak is the earliest known embryonic element involved in laterality regulation in the amniotes (Levin et al, 1995(Levin et al, , 2002Kelly et al, 2002). Furthermore, experimental subdivision of the chick blastodisc can give rise to development of the entire embryo from each blastodisc segment (Spratt and Hass, 1960), indicating plasticity of induction of both A-P and midline (or mediolateral) axes.…”

Section: Embryonic Axes In Chick Blastulae and Gastrulaementioning

confidence: 99%

“…Inset is a dorsal view of an unstained stage 3 embryo. A-C are modified from Kelly et al (2002). D: As in C but in situ hybridized with an epiblast marker, Sox-3.…”

Section: Induction Of the Initial Primitive Streakmentioning

confidence: 99%

“…In nonamniotes, particularly in amphibian gastrulation, it is well established that the anterior-posterior elongation of the body axis of the mid-gastrula and neurula is accomplished largely by the convergence and extension mechanism, which does not require changes in volume or cell numbers of a given tissue (Keller and Tibbetts, 1989;Wilson and Kelly et al, 2002). B: Transmission electron photomicrograph of a transversely sectioned streak.…”

Section: Morphogenesis Of the Initial Primitive Streakmentioning

confidence: 99%

“…C: Bilateral expression of Nodal, giving rise to randomization of left-right asymmetry, including heart looping. D: Left-sided heart looping induced by inhibition of streak midline cell death with a caspase antagonist (modified from Kelly et al, 2002). E: Physical barrier model of midline cell death in laterality regulation during early gastrulation.…”

Section: Morphogenesis Of the Initial Primitive Streakmentioning

confidence: 99%

“…The recent expression profiling of a developing chick streak has revealed that several genes exhibit distinct expression boundaries along the A-P, D-V (Lawson et al, 2001;Chapman et al, 2002), and mediolateral (Kelly et al, 2002) axes (Fig. 5), despite that cells of the initial primitive streak appear morphologically uniform.…”

Section: Patterning Of the Initial Primitive Streak Along A-p D-v Amentioning

confidence: 99%

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Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote

Matsukawa

Poh

Kelly

et al. 2004

Developmental Dynamics

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The primitive streak is the organizing center for amniote gastrulation. It defines the future embryonic midline and serves as a conduit of cell migration for germ layer formation. The migration patterns of endodermal and mesodermal precursors through the streak have been studied in great detail. Additional new breakthroughs recently have revealed the cell biological and molecular mechanisms that govern streak induction and patterning. These findings include (1) identification of the ontogeny and inductive signals of streak precursors, (2) the potential cellular mechanism of streak extension, and (3) the molecular and functional diversification along the anterior-posterior and mediolateral axes within the primitive streak. These findings indicate that amniote embryos initiate gastrulation by using both evolutionarily conserved and divergent mechanisms. The data also provide a foundation for understanding how the midline axis is defined and maintained during gastrulation of the amniotes. Developmental Dynamics 229:422-432, 2004.

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Section: Embryonic Axes In Chick Blastulae and Gastrulaementioning

confidence: 99%

“…Inset is a dorsal view of an unstained stage 3 embryo. A-C are modified from Kelly et al (2002). D: As in C but in situ hybridized with an epiblast marker, Sox-3.…”

Section: Induction Of the Initial Primitive Streakmentioning

confidence: 99%

Section: Morphogenesis Of the Initial Primitive Streakmentioning

confidence: 99%

Section: Morphogenesis Of the Initial Primitive Streakmentioning

confidence: 99%

Section: Patterning Of the Initial Primitive Streak Along A-p D-v Amentioning

confidence: 99%

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Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote

Matsukawa

Poh

Kelly

et al. 2004

Developmental Dynamics

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Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Levin¹

2006

Birth Defects Research Pt C

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Embryonic morphogenesis occurs along three orthogonal axes. While the patterning of the anterior-posterior and dorsal-ventral axes has been increasingly well-characterized, the left-right (LR) axis has only relatively recently begun to be understood at the molecular level. The mechanisms that ensure invariant LR asymmetry of the heart, viscera, and brain involve fundamental aspects of cell biology, biophysics, and evolutionary biology, and are important not only for basic science but also for the biomedicine of a wide range of birth defects and human genetic syndromes. The LR axis links biomolecular chirality to embryonic development and ultimately to behavior and cognition, revealing feedback loops and conserved functional modules occurring as widely as plants and mammals. This review focuses on the unique and fascinating physiological aspects of LR patterning in a number of vertebrate and invertebrate species, discusses several profound mechanistic analogies between biological regulation in diverse systems (specifically proposing a nonciliary parallel between kidney cells and the LR axis based on subcellular regulation of ion transporter targeting), highlights the possible importance of early, highly-conserved intracellular events that are magnified to embryo-wide scales, and lays out the most important open questions about the function, evolutionary origin, and conservation of mechanisms underlying embryonic asymmetry.

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Distinct mechanisms determine organ left‐right asymmetry patterning in an uncoupled way

Huang

et al. 2014

BioEssays

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Disruption of Nodal in the lateral plate mesoderm (LPM) usually leads to left-right (LR) patterning defects in multiple organs. However, whether the LR patterning of organs is always regulated in a coupled way has largely not yet been elucidated. In addition, whether other crucial regulators exist in the LPM that coordinate with Nodal in regulating organ LR patterning is also undetermined. In this paper, after briefly summarizing the common process of LR patterning, the most puzzling question regarding the initiation of asymmetry is considered and the divergent mechanisms underlying the uncoupled LR patterning in different organs are discussed. On the basis of cases in which different organ LR patterning is determined in an uncoupled way via an independent mechanism or at a different time, we propose that there are other critical factors in the LPM that coordinate with Nodal to regulate heart LR asymmetry patterning during early LR patterning.

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Cell death along the embryo midline regulates left–right sidedness

Cited by 26 publications

References 42 publications

Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote

Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote

Is the early left‐right axis like a plant, a kidney, or a neuron? The integration of physiological signals in embryonic asymmetry

Distinct mechanisms determine organ left‐right asymmetry patterning in an uncoupled way

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