Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection

Mohareer, Krishnaveni; Asalla, Suman; Banerjee, Sharmistha

doi:10.1016/j.tube.2018.09.007

Cited by 78 publications

(80 citation statements)

References 313 publications

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“…However, during apoptosis, lipid asymmetry is lost and PS becomes exposed on the outer leaflet of the plasma membrane 18 . The modern method of flow cytometry gives the ability to detect externalization of PS to cell cytoplasmic membrane, that is a sign of early apoptosis 10 . PS, located on the outer leaflet of the plasma membrane of apoptotic cells, connects with Annexin-V.…”

Section: Discussionmentioning

confidence: 99%

“…Cell death inducted by infection agents depends on the type of cell and its physiological state, stage of infection, infected dose and virulence factors of pathogens 6,7 . It is known that apoptosis -programmed cell death -is a normal physiological immune, modulated and genetically regulated process, activated as a response to cell stress or metabolic disorders [8][9][10] . In the system «host-organism» -«organism-pathogen», apoptosis has three pathogenic roles: apoptosis as a mechanism of elimination of «host's» cells; apoptosis as an inductor of inflammation process; apoptosis as mechanism of protection of «host-organism» 8 .…”

Section: Introductionmentioning

confidence: 99%

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Study of cell death and stages of leukocytes apoptosis in pulmonary tuberculosis patients with different antimycobacterial treatments

Шевченко¹,

Наконечна²,

Тодоріко³

et al. 2019

Arch Balk Med Union

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L'étude des types de la mort cellulaire et les stades de l'apoptose des leucocytes chez les patients atteints de la tuberculose pulmonaire aux différents programmes de traitement antimycobactérien L'objectif. D'évaluer l'état des membranes cytoplasmiques des leucocytes et étudier leur viabilité, déterminer les variétés et les stades de la mort cellulaire des leucocytes chez des patients avec tuberculose pulmonaire traités par différents schémas de traitement antimycobactérien. Matériaux et méthodes. L'étude a été réalisée sur 30 patients atteints de tuberculose pulmonaire: 1er groupe-12 patients traités par un schéma thérapeutique standard avec des médicaments en ligne; 2-ème groupe-patients traités individuellement avec les médicaments de la gamme I et II. Le groupe témoin comprenait 12 donneurs en bonne santé. L'étude a été réalisée par la cytométrie en flux sur un cytomètre en

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Study of cell death and stages of leukocytes apoptosis in pulmonary tuberculosis patients with different antimycobacterial treatments

Шевченко¹,

Наконечна²,

Тодоріко³

et al. 2019

Arch Balk Med Union

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“…The capacity of mycobacteria to hijack the type of macrophage calls death is well known, 94 but recently a new adaptive mechanism of mycobacteria was found. Mainly, following macrophage necrosis and neutrophil necrosis, a subset of mycobacteria exploits the necrotic cell-debris as a nutrientrich growing substrate.…”

Section: Persistence Of Viable Mycobacteria In Dead Cells and Necrotimentioning

confidence: 99%

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

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Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

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“… 92 – 94 However, several studies using human macrophage cell lines have indicated that virulent Mtb leads to a lower apoptosis rate than attenuated strains 95 – 97 and even inhibits apoptosis by employing a wide variety of effector proteins (which are effectively summarized in ref. 98 ) to evade host downstream immune responses. Most likely, the integrity of cell death-associated molecular pathways in certain cell lines accounts for these discrepancies.…”

Section: Introductionmentioning

confidence: 99%

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

et al. 2020

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Mycobacterium tuberculosis (Mtb) is an extremely successful intracellular pathogen that causes tuberculosis (TB), which remains the leading infectious cause of human death. The early interactions between Mtb and the host innate immune system largely determine the establishment of TB infection and disease development. Upon infection, host cells detect Mtb through a set of innate immune receptors and launch a range of cellular innate immune events. However, these innate defense mechanisms are extensively modulated by Mtb to avoid host immune clearance. In this review, we describe the emerging role of cytosolic nucleic acid-sensing pathways at the host – Mtb interface and summarize recently revealed mechanisms by which Mtb circumvents host cellular innate immune strategies such as membrane trafficking and integrity, cell death and autophagy. In addition, we discuss the newly elucidated strategies by which Mtb manipulates the host molecular regulatory machinery of innate immunity, including the intranuclear regulatory machinery, the ubiquitin system, and cellular intrinsic immune components. A better understanding of innate immune evasion mechanisms adopted by Mtb will provide new insights into TB pathogenesis and contribute to the development of more effective TB vaccines and therapies.

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Cell death at the cross roads of host-pathogen interaction in Mycobacterium tuberculosis infection

Cited by 78 publications

References 313 publications

Study of cell death and stages of leukocytes apoptosis in pulmonary tuberculosis patients with different antimycobacterial treatments

Study of cell death and stages of leukocytes apoptosis in pulmonary tuberculosis patients with different antimycobacterial treatments

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

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