Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing

Neupane, Yub Raj; Handral, Harish K; Alkaff, Syed Abdullah; Chng, Wei Heng; Venkatesan, Gopalakrishnan; Huang, Chenyuan; Lee, Choon Keong; Wang, Jiong‐Wei; Sriram, Gopu; Dienzo, Rhonnie Austria; Lu, Wen Feng; Ali, Yusuf; Czarny, Bertrand; Pastorin, Giorgia

doi:10.1016/j.apsb.2022.10.022

Cited by 21 publications

(8 citation statements)

References 70 publications

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“…[114][115][116][117] To attain overall improved in vivo stability for imaging applications, some research groups effectively loaded RBCs with magnetic particles. 118,119 To enhance blood retention, Wang et al have also shown a multimodal platform embellishing RBCs with various moieties. 99 However, only structures with sizes that remained at the micrometer level could incorporate RBCs' cloaking capabilities.…”

Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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Section: Photothermal Therapy (Ptt)mentioning

confidence: 99%

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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“…Spin cups use various sizes of membrane filters to obtain EVmimic of the desired size with the shearing force provided by centrifugal force. [110,111] Both drug packaging approaches can be used simultaneously to balance efficacy, yield, and time. Recently, transfection and coextrusion were used to obtain EV-mimic of iPSC-EC (induced pluripotent stem cells-derived endothelial cells); [112] co-extrusion and ultrasound were used to extract PMN (polymorphonuclear neutrophils)-derived EV-mimic.…”

Section: Drug Encapsulation Of Wh-eevmentioning

confidence: 99%

“…In specific studies, techniques such as qRT PCR and(or) ELISA are used to detect molecular levels associated with skin tissue cells in wounds, examples being TGF-𝛽, PDGF, COLI, and VEGF. Wound repair is a No enough proof [117] High-fat diet; Streptozotocin BG > 13.9 mmol L −1 (>1 week) T2DM [138] High-fat and high-sugar diet Streptozotocin BG > 11.1 mmol L −1 (fasting blood glucose and oral glucose tolerance test) T2DM [113] db/db mice Spontaneous T2DM [101,111] BALB/c mice Streptozotocin BG>11.…”

Section: Animal Experimentsmentioning

confidence: 99%

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Engineered Extracellular Vesicles in Wound Healing: Design, Paradigms, and Clinical Application

Liao,

Zhang,

Ouyang

et al. 2023

Small

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The severe quality of life and economic burden imposed by non‐healing skin wounds, infection risks, and treatment costs are affecting millions of patients worldwide. To mitigate these challenges, scientists are relentlessly seeking effective treatment measures. In recent years, extracellular vesicles (EVs) have emerged as a promising cell‐free therapy strategy, attracting extensive attention from researchers. EVs mediate intercellular communication, possessing excellent biocompatibility and stability. These features make EVs a potential tool for treating a plethora of diseases, including those related to wound repair. However, there is a growing focus on the engineering of EVs to overcome inherent limitations such as low production, relatively fixed content, and targeting capabilities of natural EVs. This engineering could improve both the effectiveness and specificity of EVs in wound repair treatments. In light of this, the present review will introduce the latest progress in the design methods and experimental paradigms of engineered EVs applied in wound repair. Furthermore, it will comprehensively analyze the current clinical research status and prospects of engineered EVs within this field.

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“…These cascade processes include cell migration, secretion of cytokines, interleukins, growth factors, and secretion of extracellular matrix proteins, as well as a series of complementary repair processes [ 4 , 5 , 6 ]. Finally, the missing tissue is replenished through the synergistic effects of a series of molecular, biochemical, and cellular processes, which can complete the anatomical reconstruction of the tissue and restore tissue integrity [ 7 , 8 , 9 ]. The wounds can develop into chronic wounds, such as diabetic wounds and infected wounds, which are characterized by hypoxia and infection.…”

Section: Introductionmentioning

confidence: 99%

Application of Biomedical Microspheres in Wound Healing

Yang

Zhang

Gan

et al. 2023

IJMS

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Tissue injury, one of the most common traumatic injuries in daily life, easily leads to secondary wound infections. To promote wound healing and reduce scarring, various kinds of wound dressings, such as gauze, bandages, sponges, patches, and microspheres, have been developed for wound healing. Among them, microsphere-based tissue dressings have attracted increasing attention due to the advantage of easy to fabricate, excellent physicochemical performance and superior drug release ability. In this review, we first introduced the common methods for microspheres preparation, such as emulsification-solvent method, electrospray method, microfluidic technology as well as phase separation methods. Next, we summarized the common biomaterials for the fabrication of the microspheres including natural polymers and synthetic polymers. Then, we presented the application of the various microspheres from different processing methods in wound healing and other applications. Finally, we analyzed the limitations and discussed the future development direction of microspheres in the future.

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Cell-derived nanovesicles from mesenchymal stem cells as extracellular vesicle-mimetics in wound healing

Cited by 21 publications

References 70 publications

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Engineered Extracellular Vesicles in Wound Healing: Design, Paradigms, and Clinical Application

Application of Biomedical Microspheres in Wound Healing

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