Cell Differentiation-Inducing Diterpenes from Andrographis paniculata NEES.

Identification of a Rare Sulfonic Acid Metabolite of Andrographolide in Rats

“…Therefore, the C-12 configuration of metabolite 1 could be drawn in R-form, which is in accordance with the literature assignment (Matsuda et al, 1994;Zhang and Masayoshi, 1997). Combined with the finding at 20-CH 3 had NOE effects with 19-CH 2 OH, H 2a , H 6a , H 7a , H 11␣ , and H 11␤ , and 19-CH 2 OH correlated with H 2a and H 6a , it is suggested that 20-CH 3 , and 19-CH 2 OH were located at axial orientations.…”

Apoptosis Inducing Effect Of Andrographolide On TF-47 Human Breast Cancer Cell Line

“…The andrographolide crystal was recrystalized from hot methanol. Its IR, 1 H-NMR, 13 C-NMR and MS data were in accordance with those of andrographolide (Matsuda et al,1994) and standard (Sigma, USA).…”

“…It possesses antimicrobial (Prajjal et al, 2003), anti-inflammatory (Shen et al, 2002), hypotensive ( Zhang and Tan, 1996) , antihyperglycemic ( Yu et al, 2003;Borhanuddin et al ., 1994); oxygen radical scanvenging (Shen et al, 2002), atherosclerotic ( Wang and Zhao.,1994), anti-malarial activity (Dua et al,2000), anti-HIV (Calabrese et al,2000), antiplatelet aggregation (Amroyan et al,1999), hepatic lipid peroxidation protective (Choudhury and Poddar,1984), hepatoprotective (Handa and Sarma ,1990), choleretic effect (Shukla et al, 1992), and anticancer effects (Kumar et al,2004 ;Rajagopal et al 2003;Chang, 1987;Matsuda et al, 1994 ). One of the major constituents of A. paniculata Ness is diterpene lactone such as andrographolide, which has anticancer activity in vitro in many tumor cell lines including leukemia, myeloma, HeLa, colon (HT-29), human peripheral blood lymphocytes (HPBLs), and human breast cancer MCF-7 (Satyanaraya et al, 2004).…”

Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

“…5) In Thailand, this plant was selected by the Ministry of Public Health as one of the medicinal plants to be included in "The National List of Essential Drugs A.D. 1999" (List of Herbal Medicinal Products). 6) Extensive research has revealed that Andrographis paniculata has a surprisingly broad range of pharmacological effects and some of them are extremely beneficial, such as antiinflammatory, [7][8][9][10][11] antidiarrhoeal, 12,13) antiviral, 14) anti-malarial, 15,16) hepatoprotective, [17][18][19][20][21][22][23][24][25][26][27][28][29] cardiovascular, 30,31) anticancer, [32][33][34][35][36][37][38][39] and immunostimulatory [40][41][42][43][44] activities. On the other hand, male reproductive toxicity 45) and cytotoxicity 46) of this plant have been reported as well.…”