Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers

Cha, Jung-Joon; Park, Yangkyu; Yun, Joungil; Kim, Hyeon Woo; Park, Chang-Ju; Kang, Gil Bu; Jung, Minhyun; Pak, Boryeong; Jin, Suk‐Won

doi:10.1155/2016/8484217

Cited by 9 publications

(2 citation statements)

References 29 publications

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“…Тому всі фізіологічні і патологічні процеси, що відбуваються в мембранному комплексі тканин організму впливають і на рівень реактивної складової, і, відповідно, на рівень його повного імпедансу. Найвиразніше реактивна провідність виявляється під час зондуванням високочастотним змінним струмом[79,80,81].…”

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“…В той же час встановлено, що зміни активної частини комплексного опору R (рис. 33) не досягали рівня статистичної вірогідності в жодній з досліджуваних точок, що вказує на сталість хімічного складу клітин, оскільки відомо що активний опір залежить тільки від густини та хімічного складу речовини[79,80,81].…”

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Complications of radiation therapy in cancer patients and changes in homeostasis

Krasnoselskyi,

Kulinich,

Hladkykh

2023

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The monograph is devoted to the analysis of catamnetic factors associated with an increased risk of developing late radiation complications. A retrospective analysis of 254 case histories of patients with malignant neoplasms of the cervix and 81 case histories of patients with malignant neoplasms of the breast after radiation therapy on AGAT-R, ROKUS-AM, Clinac 600C and who were hospitalized for late complications of radiation therapy in the department of radiation pathology and palliative medicine of the State Organization "Grigoriev Institute for Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine" in the period 1994–2021. The prognostic value of initial hematological and biochemical indicators, as well as clinical and anamnestic parameters in the development of late radiation complications, was established. The monograph will be useful for oncologists, oncogynecologists, radiologists, radiation therapists, radiobiologists, biochemists and students of higher education institutions of medical profile. Tables – 21, figures – 35, bibliography – 81 references.

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Complications of radiation therapy in cancer patients and changes in homeostasis

Krasnoselskyi,

Kulinich,

Hladkykh

2023

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Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells

Low

Chan

Tay

2021

Adv Funct Materials

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Cellular senescence refers to a state of irreversible arrest of cell proliferation in response to various forms of cellular stress. It is known that the accumulation of senescent cells is a hallmark of aging, and mounting evidence has shown that the chronic accumulation of senescent cells is a significant contributor to various deleterious age-related pathologies. To limit the detrimental impacts of cellular senescence, there has been growing interest in targeted delivery of therapeutics to senescent cells to treat age-related pathologies and promote healthy aging. Two popular strategies include the elimination of senescent cells using senolytic drugs, and rejuvenation of senescent cells. To that end, it is integral that the delivery of senolytics, senomorphics or rejuvenating biomolecules to senescent cells are highly selective to enhance delivery efficacy and safety. However, there is little understanding of how senescence-associated biophysical changes such as cellular size and stiffness can be exploited for targeted therapeutics delivery. In this review, the biomolecular and biophysical markers of senescence along with senescence models and emerging therapeutics are first described. This review then focuses on how biophysical properties can be exploited for targeted therapeutics delivery, using approaches like nanoparticles, electroporation, sonoporation, photoporation and high aspect-ratio nanostructures to senescent cells.

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Rheo-impedance behavior of cellulose nanofibers produced by mechanical processing

Yamagata,

Takasaki,

Miyamoto

2024

Cellulose

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CNFs are one of the renewable and the sustainable resources with low environmental impact and have various characteristics such as increased strength and weight reduction when added to resins. Since CNFs are one of the new materials that can fulfill the goals of the Sustainable Development Goals (hereafter abbreviated as SDGs), many researchers have been studying the nano-fibrillation of wood fibers. From the viewpoint of SDGs, it is necessary to avoid using a large amount of chemical agents and consuming a large amount of energy for the production of CNFs. To realize these requirements, it is important to find a way to industrially utilize CNFs containing insufficiently nanosized fibers, and for these purposes, it is essential to evaluate the physical properties of these CNFs from multiple perspectives. Cellulose fibers are intrinsically insulating materials, but how their electrochemical properties are changed by nano-fibrillization has been little studied. Therefore, we decided to clarify the relationship between the size of CNFs and the electrochemical impedance properties of the CNF suspensions containing un-fibrillated fibers, which were prepared by a wet refinement system. The fiber diameter remained constant as the number of mechanical treatments (hereafter referred to as the “number of collisions”) increased. On the other hand, the cumulative medium volume diameter, D50, defined as the apparent fiber length (hereafter referred to as the “fiber length”, in microns), significantly decreases with the increasing number of collisions. The rheo-impedance |Z| of the CNF suspension remained nearly constant in the intermediate frequency range of 103–106 Hz, even if the internal structure of the system was deformed by the increasing shear rate. This means that the electrochemical properties of the CNFs are independent of the changes in the macroscopic aggregation structure. Furthermore, the internal resistance R1 calculated from the impedance |Z| characteristics (Nyquist plot) became decreased with the increasing number of collisions, indicating a proportional relationship between the resistance R1 and the CNF fiber length, D50. This suggests that R1 related to the resistance caused by the electrolyte in the suspensions or the protons dissociated by the hydration of the hydroxyl groups of the cellulose molecule as they move across the gaps between the microfibrils. Based on these results, it appears that the electrochemical properties of the CNF suspensions are independent of the changes in the macroscopic aggregation structure and simply depend on the fiber length, in other words, the electrochemical properties are a useful method for indirectly evaluating the fiber length of the CNFs.

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Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers

Cited by 9 publications

References 29 publications

Complications of radiation therapy in cancer patients and changes in homeostasis

Complications of radiation therapy in cancer patients and changes in homeostasis

Targeted Therapeutics Delivery by Exploiting Biophysical Properties of Senescent Cells

Rheo-impedance behavior of cellulose nanofibers produced by mechanical processing

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