2023
DOI: 10.1021/acs.jproteome.3c00190
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Cell-Engineered Recombinant α-Synuclein: A Gage R&R Validated Protocol

Harsh Thakkar,
Sayan Chatterjee,
Purvi Saxena
et al.

Abstract: α-Synuclein (α-Syn) misfolding and its presence in Lewy bodies are observed in almost all Parkinson's disease (PD) patients. Basic biomedical research would benefit from a quick, low-cost approach to purifying α-Syn and developing in vitro and in vivo models for PD. Several research groups utilize PFF-based models, yet the production of α-Syn PFFs is inconsistent, resulting in nonconclusive findings. Some research laboratories prepare recombinant α-Syn (r α-Syn) by molecular cloning to overexpress α-Syn with v… Show more

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