Cell groups in the tuber cinereum of the dog, with a discussion of their function

Morgan, Lawrence O.

doi:10.1002/cne.900510203

Cited by 24 publications

(2 citation statements)

References 29 publications

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“…Ericson et al, 1987;Inagaki et al, 1990;Kohler et al, 1985;Staines et al, 1987). However, historically in the cat, "tuberomammillary nucleus" refers specifically to a small nucleus at the base of the brain, ventrolateral to the fornix in posterior hypothalamus and bordered caudally by the cerebral peduncle and the mammillary nuclei (Bleier, 1961;Morgan, 1930), which contains only a small portion of the histaminergic neurons we see labeled. We acknowledge the contemporary nomenclature for the histaminergic cells in the brain.…”

Section: Histamine-immunoreactive Cell Bodiesmentioning

confidence: 99%

The histaminergic innervation of the lateral geniculate complex in the cat

1993

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The histaminergic innervation of the thalamic dorsal and ventral lateral geniculate nuclei and the perigeniculate nucleus of the cat was examined immunohistochemically by means of an antibody to histamine.We find histamine-immunoreactive neurons in the cat brain are concentrated in the ventrolateral portion of the posterior hypothalamus, confirming a previous report. However, this cell group also spreads into medial, dorsal, and extreme lateral regions of the posterior hypothalamus and extends as far rostral as the optic chiasm.Histamine-labeled fibers cover all regions of the lateral geniculate complex, but the density of labeling varies. The ventral lateral geniculate nucleus (vLGN) is most densely labeled, the A laminae of the dorsal lateral geniculate are sparsely labeled, and the geniculate C laminae and the perigeniculate nucleus show intermediate amounts of label. Thus, histaminergic fibers demonstrate a predilection for zones innervated by the W-cell system. Labeled fibers exhibit few branchings and numerousen passantswellings, lending a beaded appearance. The vLGN showed more instances of fibers with larger-sized swellings (up to 2 μm).Following injections of biotinylated tracers into the hypothalamus, we find labeled fibers throughout the lateral geniculate complex. The anterogradely labeled fibers resemblethe histaminergic fibers in morphology, distribution, and relative bouton size. Thus, the hypothalamus appears to be the source of the histaminergic fibers in the lateral geniculate complex.Histamine-labeled fibers in the dorsal lateral geniculate nucleus (dLGN) exhibit uncommon ultrastructural morphology. Many extremely large, round, or elliptical vesicles fill the fiber swellings. Swellings are directly apposed to a variety of other dendritic and axonal profiles, but thus far no convincing synaptic contacts have been seen. The distribution and appearance of these histaminergic fibers resembles those reported for serotonergic fibers.Our results support the idea that histamine works nonsynaptically as a neuromodulator in the lateral geniculate complex, affecting the level of visual arousal.

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Section: Histamine-immunoreactive Cell Bodiesmentioning

confidence: 99%

The histaminergic innervation of the lateral geniculate complex in the cat

1993

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“…This opinion disagrees with my results, because there is quite a different nucleus at the base of the middle part of the hypothalam us, called the tuberom am illary nucleus. It occurs in the hypothalam us of the dog [Morgan, 1930;S.mialowski, 1968], but has not been observed in the m acaque [Crough, 1934], neither does it occur in the hum an hypothalam us [ K uhlenbeck, 1954].…”

Section: Discussionmentioning

confidence: 99%