Cell-Inspired Biomaterials for Modulating Inflammation

Bender, Elizabeth C.; Kraynak, Chelsea A.; Huang, Wenbai; Suggs, Laura J.

doi:10.1089/ten.teb.2020.0276

Cited by 9 publications

(5 citation statements)

References 127 publications

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“…93 Another approach undertaken to modulate the immune responses against implanted biomaterials is the incorporation of anti-inflammatory cytokines on their surface. 94 In a study, a polypropylene mesh scaffold was coated with interspersed layers of chitosan, interleukin-4 (IL-4), and dermatan sulphate. IL-4 elution was observed from the surface in vitro, which led to the increased expression of anti-inflammatory markers on macrophages and a better integration of the implant into the tissues due to the decrease in fibrous capsule thickness.…”

Section: Reviewmentioning

confidence: 99%

Navigating the challenges and exploring the perspectives associated with emerging novel biomaterials

Rajeev,

Kansara,

Bhatia

2024

Biomater. Sci.

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Section: Reviewmentioning

confidence: 99%

Navigating the challenges and exploring the perspectives associated with emerging novel biomaterials

Rajeev,

Kansara,

Bhatia

2024

Biomater. Sci.

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“…In fact, both approaches have been employed in TBI therapy. Biologically active biomaterials may promote recovery and repair by themselves and can also be used as delivery agents for factors that assist in tissue regeneration, such as cells, ECM proteins and growth factors, angiogenic factors, anti-inflammatory cytokines, and antioxidants [119][120][121] (Figure 2). Furthermore, using biomaterials to deliver cells in combination with neurotrophic growth factors or ECM proteins can properly guide the differentiation of stem cells and assist in tissue regeneration [121].…”

Section: Biomaterials and Their Mechanisms Of Action In Tbimentioning

confidence: 99%

Biomaterials in Traumatic Brain Injury: Perspectives and Challenges

Aqel,

Al-Thani,

Haider

et al. 2023

Biology

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Traumatic brain injury (TBI) is a leading cause of mortality and long-term impairment globally. TBI has a dynamic pathology, encompassing a variety of metabolic and molecular events that occur in two phases: primary and secondary. A forceful external blow to the brain initiates the primary phase, followed by a secondary phase that involves the release of calcium ions (Ca2+) and the initiation of a cascade of inflammatory processes, including mitochondrial dysfunction, a rise in oxidative stress, activation of glial cells, and damage to the blood–brain barrier (BBB), resulting in paracellular leakage. Currently, there are no FDA-approved drugs for TBI, but existing approaches rely on delivering micro- and macromolecular treatments, which are constrained by the BBB, poor retention, off-target toxicity, and the complex pathology of TBI. Therefore, there is a demand for innovative and alternative therapeutics with effective delivery tactics for the diagnosis and treatment of TBI. Tissue engineering, which includes the use of biomaterials, is one such alternative approach. Biomaterials, such as hydrogels, including self-assembling peptides and electrospun nanofibers, can be used alone or in combination with neuronal stem cells to induce neurite outgrowth, the differentiation of human neural stem cells, and nerve gap bridging in TBI. This review examines the inclusion of biomaterials as potential treatments for TBI, including their types, synthesis, and mechanisms of action. This review also discusses the challenges faced by the use of biomaterials in TBI, including the development of biodegradable, biocompatible, and mechanically flexible biomaterials and, if combined with stem cells, the survival rate of the transplanted stem cells. A better understanding of the mechanisms and drawbacks of these novel therapeutic approaches will help to guide the design of future TBI therapies.

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“…A cell type that can be readily targeted with nanoparticles to ameliorate symptoms in a variety of conditions, like cancer and chronic inflammatory diseases, is the macrophage. , Macrophages are responsible for disease progression and severity in chronic autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes mellitus, so they are a good therapeutic target. − Macrophages also readily endocytose nano- and microparticles, making targeting them easier than many other cell types.…”

Section: Introductionmentioning

confidence: 99%

Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake

Bender,

Sircar,

Taubenfeld

et al. 2024

ACS Biomater. Sci. Eng.

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Macrophage uptake of nanoparticles is highly dependent on the physicochemical characteristics of those nanoparticles. Here, we have created a collection of lipid-polymer nanoparticles (LPNPs) varying in size, stiffness, and lipid makeup to determine the effects of these factors on uptake in murine bone marrow-derived macrophages. The LPNPs varied in diameter from 232 to 812 nm, in storage modulus from 21.2 to 287 kPa, and in phosphatidylserine content from 0 to 20%. Stiff, large nanoparticles with a coating containing phosphatidylserine were taken up by macrophages to a much higher degree than any other formulation (between 9.3× and 166× higher than other LPNPs). LPNPs with phosphatidylserine were taken up most by M2-polarized macrophages, while those without were taken up most by M1-polarized macrophages. Differences in total LPNP uptake were not dependent on endocytosis pathway(s) other than phagocytosis. This work acts as a basis for understanding how the interactions between nanoparticle physicochemical characteristics may act synergistically to facilitate particle uptake.

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Cell-Inspired Biomaterials for Modulating Inflammation

Cited by 9 publications

References 127 publications

Navigating the challenges and exploring the perspectives associated with emerging novel biomaterials

Navigating the challenges and exploring the perspectives associated with emerging novel biomaterials

Biomaterials in Traumatic Brain Injury: Perspectives and Challenges

Modulating Lipid-Polymer Nanoparticles’ Physicochemical Properties to Alter Macrophage Uptake

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