Cell-Mediated Immunity in Long Term Transplant Patients

Thomas, Judith M.; Kaplan, A. M.; Thomas, Francis T.; Lee, H. M.

doi:10.1007/978-1-4684-3300-5_24

Cited by 2 publications

(1 citation statement)

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“…Es gibt aber ,,Ausnahmeffille", die einen Weg ffir eine m6gliche Organtoleranz erkennen lassen: trotz grol3er genetischer Differenz von Spender und Empffinger werden Nierentransplantate bei minimaler immunsuppressiver Therapie fiber Jahre behalten, und die in vitro-Untersuchungen bestimmter immunologischer Reaktionen haben bei einigen Organempffingern zu einer spezifischen immunologischen Hyporeaktivitfit gegenfiber dem Transplantat geffihrt [53]. Zu diesen "Ausnahmef~tllen" scheinen auch allogene Lebertransplantate zu geh6ren.…”

Section: Schliisselw6rter: Orthotope Allogene Lebertransplantation -Aunclassified

Die allogene Lebertransplantation

Bockhorn

1981

Res. Exp. Med.

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Pigs usually reject MHC incompatible liver allografts less aggressively than skin or kidney allografts. Orthotopic liver allografts can survive undefinitely without any immunosuppression. The liver is considered to be an immunologically privileged organ. Despite this phenomenon, morphological changes and deranged liver function due to rejection reaction are regularly seen; their intensity depends on the histocompatibility antigen disparity between donor and recipient. In long-term survivors the continuous exposure of the recipient's immune system to the liver allograft results in an increasing fibrosis which can turn into liver cirrhosis being considered as the result of chronic rejection. The cholestasis represents a remarkable feature, which is mainly due to perfusion, infection and immunological reaction.

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Section: Schliisselw6rter: Orthotope Allogene Lebertransplantation -Aunclassified