Cell mediated lympholysis defines two subgroups of HLA Bw44 which differ in their platelet expression of Bw44

Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes.

“…However, little is known about the relevance of particular regions of the molecule in determining the specificity of CTL recognition and MHC restriction. A way of approaching this issue takes advantage of the fact that various well-defined serological specificities may be further divided into several subtypes by specific CTL (7)(8)(9)(10)(11)(12)(13)(14). Detailed biochemical analyses of some of these naturally occurring variants (15)(16)(17)(18)(19) have shown that the different subsets of a given serological specificity differ from each other in a very limited number of amino acid residues.…”