Cell permeabilization using a non-thermal plasma

Leduc, Mathieu; Guay, David R.P.; Leask, Richard L.; Coulombe, Sylvain

doi:10.1088/1367-2630/11/11/115021

Cited by 196 publications

(154 citation statements)

References 19 publications

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“…1a) [71]- [74] as an example and discuss how some of the current understanding of plasma-cell interaction is used in CAP designs. Formed in a flowing gas, the CAP jet is well suited for precision and localised treatment, such as root canal disinfection [75]- [77] and cell transfection [78]. Some of the current CAP jets rely on the generation of highintensity plasma in the upstream electrode region (sustained in a radial-directed electric field) and its axial diffusion towards a downstream sample is often unaided.…”

Section: Modes Of Plasma Interaction With Biological Samplesmentioning

confidence: 99%

“…This should enable a greater passage efficacy of plasma ROS/RNS through aqueous channels of living tissues. It is worth noting that the delivery of plasma ROS through the membrane of a mammalian cell is also possible as indicated in early in-vitro evidence of cell permeation of plasma species [78]. Penetration of plasma species through the membrane of a bacterial cell is possibly more difficult because of much narrow channels through the membrane (~up to a few tens of nanometres in diameter).…”

Section: Plasma Penetrationmentioning

confidence: 99%

“…There have been some reports of plasma-mediated cell permeation [78], and possible mechanisms may include surface deposition of charges, electroporation by global and local electric field, exothermic recombination of excited species and radicals, and locally released heat. Energy and/or heat can be released by either plasmas or nanoparticles, though via different routes.…”

Section: Synergy In Cell Permeation and Cellular Manipulationmentioning

confidence: 99%

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Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

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To cite this version:M G Kong, M Keidar, K Ostrikov. Plasmas meet nanoparticleswhere synergies can advance the frontier of medicine. Journal of Physics D: Applied Physics, IOP Publishing, 2011, 44 (17) AbstractNanoparticles and low-temperature plasmas have been developed, independently and often along different routes, to tackle the same set of challenges in biomedicine. There are intriguing similarities and contrasts in their interactions with cells and living tissues, and these are reflected directly in the characteristics and scope of their intended therapeutic solutions, in particular their chemical reactivity, selectivity against pathogens and cancer cells, safety to healthy cells and tissues, and targeted delivery to diseased tissues. Time has come to ask the inevitable question of possible plasma-nanoparticle synergy and the related benefits to the development of effective, selective, and safe therapies for modern medicine. This perspective article offers a detailed review of the strengths and weakenesses of nanomedicine and plasma medicine as a stand-alone technology, and then provides a critical analysis of some of the major opportunities enabled by synergising the nanotechnology and the plasma technology. It is shown that the plasma-nanoparticle synergy is best captured through the plasma nanotechnology and its benefits for medicine are highly promising.

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Section: Modes Of Plasma Interaction With Biological Samplesmentioning

confidence: 99%

Section: Plasma Penetrationmentioning

confidence: 99%

Section: Synergy In Cell Permeation and Cellular Manipulationmentioning

confidence: 99%

See 1 more Smart Citation

Plasmas meet nanoparticles—where synergies can advance the frontier of medicine

Kong¹,

Keidar²,

Ostrikov³

2011

J. Phys. D: Appl. Phys.

109

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“…5 Little is known of the influence that plasma has on DNA. While qualitative work is a good indicator, 9,10 it is vital to quantitatively determine the nature of this influence before any potential application on living tissue can be realized. For applications such as skin treatments and wound healing, it is vital that DNA damage is avoided.…”

mentioning

confidence: 99%

Cold atmospheric pressure plasma jet interactions with plasmid DNA

O’Connell

Cox

Hyland

et al. 2011

Applied Physics Letters

148

101

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The effect of a cold (<40 °C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks.

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“…저온 플라즈마는 비활성표면의 살균이나 [4][5][6] 표면 조작을 통한 세포부착의 조절 [7,8]에 적용되어 왔다. 또한 저온 플라즈마 는 혈액응고를 유도하고 [5,9], 세포증식을 촉진하며 [10], 세 1 포의 transfection을 향상하는 [11] 등 의료 및 생물학 연구 분 야에서 다양하게 적용되고 있다. 최근 연구들을 살펴보면 생 체에 직접적으로 적용하기 위한 저온 플라즈마의 필요성이 더욱 부각되고 있으며 이에 따른 연구들이 늘어나고 있다 [1,5].…”

Section: Introductionunclassified