Cell–polymer interactions of fluorescent polystyrene latex particles coated with thermosensitive poly(N-isopropylacrylamide) and poly(N-vinylcaprolactam) or grafted with poly(ethylene oxide)-macromonomer

Vihola, Henna; Marttila, Anna-Kaisa; Pakkanen, Jukka S.; Andersson, Mirja; Laukkanen, Antti; Kaukonen, Ann Marie; Tenhu, Heikki; Hirvonen, Jouni

doi:10.1016/j.ijpharm.2007.04.020

Cited by 41 publications

(31 citation statements)

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“…Adjustment of the LCST of PNIPAAm has been achieved by copolymerizing with hydrophilic or hydrophobic monomers rendering the overall hydrophilicity of the polymer higher or lower respectively [3,5,6,15]. Other polymers with thermoresponsive properties include poly(N,N-diethylacrylamide) (PDEAAm) with an LCST over the range of 25 to 32 °C, poly(N-vinlycaprolactam) (PVCL) [7,8,16] with an LCST between 25 and 35 °C, poly [2-(dimethylamino)ethyl methacrylate] (PDMAEMA) [17][18][19][20][21][22] with an LCST of around 50 °C [21] and poly(ethylene glycol) (PEG), also called poly(ethylene oxide) (PEO) whose LCST is around 85 °C [23][24][25][26]. It should be noted the LCST is affected by the size of the side groups.…”

Section: Open Accessmentioning

confidence: 99%

“…"Smart" materials, i.e., materials that have the ability to respond to external stimuli, represent one of the most exciting and immerging class of materials [1][2][3][4][5][6][7][8][9]. One of the main groups of "smart" materials is based on polymers because they are cheaper and more easily tailored than metals or ceramics.…”

Section: Introductionmentioning

confidence: 99%

“…One of the main groups of "smart" materials is based on polymers because they are cheaper and more easily tailored than metals or ceramics. These polymeric "smart" materials can respond to stimuli such as pH, temperature, ionic strength, electric or magnetic field, light and/or chemical and biological stimuli and consequently have a wide range of applications that include sensors, drug delivery, gene delivery and tissue engineering [1][2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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Thermoresponsive polymers are a class of "smart" materials that have the ability to respond to a change in temperature; a property that makes them useful materials in a wide range of applications and consequently attracts much scientific interest. This review focuses mainly on the studies published over the last 10 years on the synthesis and use of thermoresponsive polymers for biomedical applications including drug delivery, tissue engineering and gene delivery. A summary of the main applications is given following the different studies on thermoresponsive polymers which are categorized based on their 3-dimensional structure; hydrogels, interpenetrating networks, micelles, crosslinked micelles, polymersomes, films and particles.

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Section: Open Accessmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive Polymers for Biomedical Applications

2011

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“…The properties of biomembranes are sig nificantly dependent on environmental factors, such as temperature, pH and salt concentration [78][79][80]. For instance, the membrane fluidity decreases and changes from the liquid-crystal line to gel phase with decreasing temperature, which inhibits NM-biomembrane interactions [76,80].…”

Section: Future Science Groupmentioning

confidence: 99%

“…For instance, the membrane fluidity decreases and changes from the liquid-crystal line to gel phase with decreasing temperature, which inhibits NM-biomembrane interactions [76,80]. The environmental pH and salt concen tration can alter the mechanical and electrical properties of the membrane.…”

Section: Future Science Groupmentioning

confidence: 99%

Advances in The Understanding of Nanomaterial–Biomembrane Interactions and Their Mathematical and Numerical Modeling

Lin

et al. 2013

Nanomedicine

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The widespread application of nanomaterials (NMs), which has accompanied advances in nanotechnology, has increased their chances of entering an organism, for example, via the respiratory system, skin absorption or intravenous injection. Although accumulating experimental evidence has indicated the important role of NM–biomembrane interaction in these processes, the underlying mechanisms remain unclear. Computational techniques, as an alternative to experimental efforts, are effective tools to simulate complicated biological behaviors. Computer simulations can investigate NM–biomembrane interactions at the nanoscale, providing fundamental insights into dynamic processes that are challenging to experimental observation. This paper reviews the current understanding of NM–biomembrane interactions, and existing mathematical and numerical modeling methods. We highlight the advantages and limitations of each method, and also discuss the future perspectives in this field. Better understanding of NM–biomembrane interactions can benefit various fields, including nanomedicine and diagnosis.

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