Cell proliferation and cell death are disturbed during prenatal and postnatal brain development after uranium exposure

Legrand, M; Elie, Christelle; Stéfani, Johanna; Flores, Natasha; Culeux, Cécile; Delissen, Olivia; Ibanez, Chrystelle; Lestaevel, Philippe; Eriksson, Per; Dinocourt, Céline

doi:10.1016/j.neuro.2015.10.007

Cited by 18 publications

(14 citation statements)

References 37 publications

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“…The concentrations of U in rats exposed to 120 mg/L were significantly higher (around three times as high) in comparison with the 40 mg/L group (Table 1). These results are in line with the data of Legrand and collaborators [10], and together demonstrate that the dose-dependent accumulation of U occurred in the bodies of pups from postnatal day 0 until adulthood throughout exposure.…”

Section: Resultssupporting

confidence: 92%

“…In summary, no significant change was observed after U exposure during the development of the DG at gestational day 13, postnatal day 0 and day 5 [10], as well as at 2 months (present study). However, U exposure increased cell proliferation by increasing the production of dividing neural progenitors in the dentate neuroepithelium of fetuses [10]. Correlated with this, exposure to U seems to promote neural cell proliferation during prenatal development [11].…”

Section: Resultsmentioning

confidence: 48%

“…Studies of animal models show that parental exposure to U during gestation and lactation impairs behaviors such as learning, activity, exploration, and emotionality in offspring [7,8,9]. In our model, in which U exposure began from the first day of gestation, we recently showed depressive-like behavior in neonatal rats, as well as modifications in the signaling pathways of neuronal cell proliferation and neuronal differentiation during prenatal and postnatal development of the hippocampus [10,11]. Using the same model to study specific time points allowed us to follow the neurobehavioral consequences as well as the progression of neurogenesis, from embryogenesis to adulthood in animals from dams exposed to depleted U (DU).…”

Section: Introductionmentioning

confidence: 78%

“…The study of specific time points in our model of U exposure from gestation day 1 allowed us to follow the progression of neurogenesis and more specifically the proliferative state by BrdU incorporation in the DG, from embryogenesis to adulthood in animals from the U-exposed dams ([10,11] and present work). In summary, no significant change was observed after U exposure during the development of the DG at gestational day 13, postnatal day 0 and day 5 [10], as well as at 2 months (present study).…”

Section: Resultsmentioning

confidence: 99%

“…Pregnant rats were exposed to 0, 40, or 120 mg/L, i.e., 0, 2, or 6 mg/kg/day, based on 100 mL of daily water consumption. Thus, rats were exposed to DU throughout life, from embryo to adult stages [10]. For each group (0, 40 and 120 mg/L), 24 pups from eight litters at 2 months of age were taken for analysis.…”

Section: Methodsmentioning

confidence: 99%

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Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Dinocourt

Culeux

Legrand

et al. 2017

IJERPH

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Uranium exposure leads to cerebral dysfunction involving for instance biochemical, neurochemical and neurobehavioral effects. Most studies have focused on mechanisms in uranium-exposed adult animals. However, recent data on developing animals have shown that the developing brain is also sensitive to uranium. Models of uranium exposure during brain development highlight the need to improve our understanding of the effects of uranium. In a model in which uranium exposure began from the first day of gestation, we studied the neurobehavioral consequences as well as the progression of hippocampal neurogenesis in animals from dams exposed to uranium. Our results show that 2-month-old rats exposed to uranium from gestational day 1 displayed deficits in special memory and a prominent depressive-like phenotype. Cell proliferation was not disturbed in these animals, as shown by 5-bromo-2′deoxyuridine (BrdU)/neuronal specific nuclear protein (NeuN) immunostaining in the dentate gyrus. However, in some animals, the pyramidal cell layer was dispersed in the CA3 region. From our previous results with the same model, the hypothesis of alterations of neurogenesis at prior stages of development is worth considering, but is probably not the only one. Therefore, further investigations are needed to correlate cerebral dysfunction and its underlying mechanistic pathways.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 48%

Section: Introductionmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Dinocourt

Culeux

Legrand

et al. 2017

IJERPH

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Uranium and Thorium

Gaitens,

McDiarmid,

Squibb

et al. 2023

Patty's Toxicology

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Uranium is a radioactive metal, the 92nd element in the periodic table, and a member of the actinide series. With the advent of the nuclear age, uranium now occupies a key position in nuclear weapons and energy. Uranium in its depleted form has also been used for military armament and weaponry. Small amounts of uranium are also used in chemicals, ceramics, glass, and photography. Due to uranium's natural radioactivity, both radiological and chemical methods are available for quantitative measurements of uranium in environmental samples and human tissues. Kidney damage has been seen in humans and animals after inhaling or ingesting uranium compounds. Studies in animals have shown that inhalation exposure to insoluble uranium compounds can result in lung damage . Thorium is the 90th element in the periodic table and also a member of the actinide series. Thorium is used as a source of atomic fuel, in the production of incandescent mantles, as an alloying element with magnesium, tungsten, and nickel, and in the past was used as a diagnostic agent for systemic radiological studies. Thorium is primarily a radioactive hazard in humans; but, like uranium, also has chemical toxicity. Breathing high levels of thorium dust results in an increased risk of lung disease. Liver diseases and effects on the blood were found in people injected with thorotrast, a thorium compound injected into the body as a radiographic contrast medium between the years 1928 and 1955.

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Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings?

Dinocourt¹

2017

Advances in Neurobiology

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Increasing industrial and military use of uranium has led to environmental pollution, which may result in uranium reaching the brain and causing cerebral dysfunction. A recent literature review has discussed data published over the last 10 years on uranium and its effects on brain function (Dinocourt C, Legrand M, Dublineau I, et al., Toxicology 337:58-71, 2015). New models of uranium exposure during neonatal brain development and the emergence of new technologies (omics and epigenetics) are of value in identifying new specific targets of uranium. Here we review the latest studies of neurogenesis, epigenetics, and metabolic dysfunctions and the identification of new biomarkers used to establish potential pathophysiological states of neurodevelopmental and neurodegenerative diseases.

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Cell proliferation and cell death are disturbed during prenatal and postnatal brain development after uranium exposure

Cited by 18 publications

References 37 publications

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Chronic Exposure to Uranium from Gestation: Effects on Behavior and Neurogenesis in Adulthood

Uranium and Thorium

Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings?

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