Cell proliferation, apoptosis, and angiogenesis in non-functional pituitary adenoma: association with tumor invasiveness

Ghadir, Maliheh; Hosseinkhan, Nazanin; Panahi-Shamsabad, Mahshid; Ghorbani, Mohammad; Akbari, Hamideh; Mehrjardi, Ali Zare; Honardoost, Maryam; Jafar-Mohammadi, Bahram

doi:10.1007/s12020-020-02366-6

Cited by 10 publications

(13 citation statements)

References 48 publications

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“…The results showed that it significantly inhibited the proliferation of HCC cells, which was related to the fact that sterols could inhibit the cell cycle of tumor cells. Cell proliferation specific antigen Ki67 is an important protein for the detection of cell proliferation activity [ 21 , 22 ], which is often detected by immunohistochemistry. Besides, proliferating cell nuclear antigen and micro chromosome maintenance proteins are also the basic proliferation markers commonly used to evaluate the growth fraction of cell populations [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes

et al. 2022

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Hepatocellular carcinoma (HCC) is a common digestive malignant tumor with high morbidity and mortality worldwide, however, the treatment of HCC and prognosis of patients are not optimistic, finding more effective treatments are imperative. Taraxacum officinale (L.) Weber ex F.H.Wigg is a perennial herb of compositae, and our study has demonstrated that Taraxacum officinale polysaccharide has certain anti-tumor effect on HCC cells. Taraxasterol (TS) is a natural product extracted from Taraxacum officinale with strong physiological, pharmacological and biological activities, but the effect of TS on HCC is yet to be determined. Therefore, the aim of this study is to explore the effect of dandelion sterol on HCC in vivo and in vitro. The results showed that TS significantly inhibited the proliferation, induced apoptosis and blocked cell cycle in HCC cell lines HepG2 and Huh7 cells in vitro. TS inhibited the tumor growth of H22 bearing mice and the expression of Ki67 in vivo. More importantly, TS regulated the immunity of H22 bearing mice by elevating the ratio of CD4+ T cells in spleen, and increasing the number of T cell infiltration in tumor tissue. Except immunomodulation, the mechanism of tumor growth inhibition may be related to the regulation of apoptosis related proteins and IL-6/STAT3 pathway. TS significantly inhibited the growth of HCC cells both in vitro and in vivo. The study would provide a theoretical basis for the new application of TS and the adjuvant treatment of malignant tumor with traditional Chinese medicine.

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Section: Discussionmentioning

confidence: 99%

Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes

et al. 2022

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“…In addition, abnormalities of well-known angiogenesis inhibitors such as platelet derived growth factor (PEDF), SRc homology-2-domain-containing phosphatase-1 (SHP-1), endostatin 38,47,58,85 and angiostatin 38,47,86,87,89 are also important in the occurrence and development of these two diseases. For example, PEDF: high levels of PEDF are closely associated with diabetic retinopathy and wound healing.…”

Section: Discussionmentioning

confidence: 99%

“…57 Similar to VEGF, FGF also exerts its effects by binding to receptors. 58 Besides, FGF, transforming growth factor (TGF-β), and PDGF can jointly promote VEGF expression. Basic FGF (bFGF) and prostaglandin E1 (PGE1), members of the FGF family, are believed to have synergistic effects, and the effect depends on the number of up-regulated VEGF.…”

Section: Fgfmentioning

confidence: 99%

“…59 Besides, endocan is also believed to have a regulatory effect on bFGF. 58 Due to the secretion of bFGF by tumor cells themselves, TAMs, and cancer associated fibroblasts (CAFs), the carrying of exosomes, and the promoting effect of COX-2/ mPGES-1, FGF is highly expressed in the microenvironment of various tumors. 6,31,32,38,50,60 However, in diabetes, different experiments have drawn different conclusions: some believe that the expression of FGF is increased, while others believe that there is no abnormality.…”

Section: Fgfmentioning

confidence: 99%

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Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Tan¹,

Zang²,

Wang³

et al. 2021

DMSO

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Angiogenesis, as a process occurring under the regulation of a variety of factors, is one of the important ways of vascular development. It coexists in a variety of pathological and physiological processes. Now a large number of studies have proved that tumor growth, metastasis, and various vascular complications of diabetes are closely related to angiogenesis, and an increasing number of studies have shown that there are many common factors between the two. But angiogenesis is the opposite of the two: it is enhanced in tumors and suppressed in diabetes. Therefore, this review discusses the causes of the phenomenon from the expression of various factors affecting angiogenesis in these two diseases and their effects on angiogenesis in the relevant microenvironment, as well as the application status of these factors or cells as therapeutic targets in the treatment of these two diseases.

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“…Interestingly, some patients did not have a high Ki67 index but also showed tumor recurrence. On the contrary, some patients had a Ki67 index of more than 3%, but no tumor recurrence was found during long-term followup (11,15,16). Some studies have shown that p53 and VEGF are related to tumor invasiveness, but the relationship between p53 and tumor recurrence is still unclear.…”

Section: Introductionmentioning

confidence: 98%

Identification and Verification of SLC27A1, PTBP1 and EIF5A With Significantly Altered Expression in Aggressive Pituitary Adenomas

Cheng

Sun²,

Nie³

et al. 2022

Front. Surg.

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BackgroundAggressive pituitary adenoma encircling the internal carotid artery has a poor clinical prognosis because of a high surgical risk and a high recurrence rate. This seriously affects patients’ quality of life and yet there is no effective medical treatment. The European Diagnostic Guidelines have recommended the use of temozolomide (TMZ) for these aggressive pituitary adenomas, but the treatment remission rate has been less than 50%.MethodsIn this study, transcriptome sequencing of pituitary tumour tissues and TMZ-treated pituitary tumour cell lines were employed to explore the significance gene expressions affecting the efficacy of TMZ treatment for pituitary tumours. To clarify the roles of these gene expressions, six adult patients with pituitary adenomas treated in Tiantan Hospital from 2015 to 2020 and a pituitary adenoma cell line (Att20 sensitive to TMZ treatment) were analyzed by mRNA transcriptome sequencing. The differentially expressed genes were assayed by analyzing the sequencing results, and the expression level of these genes was further verified by immunohistochemistry. In addition, Ki67, VEGF, and p53 of the tumour tissues were also verified by immunohistochemistry.ResultsIn tumour tissues, mRNA sequencing showed that PTBP1 and EIF5A were significantly overexpressed in primary pituitary adenomas and SLC27A1 was significantly overexpressed in aggressive pituitary adenomas. Also in the pituitary adenoma cell line (AtT20), SLC27A1 expression levels were suppressed by TMZ treatment. Subsequent immunohistochemistry confirmed the sequencing results.ConclusionHigh expression of SLC27A1 and low expression of EIF5A and PTBP1 may be potential indicators to predict the progression of aggressive pituitary adenomas, and patients with high SLC27A1 subtype may be sensitive to TMZ in clinical treatments.

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Cell proliferation, apoptosis, and angiogenesis in non-functional pituitary adenoma: association with tumor invasiveness

Cited by 10 publications

References 48 publications

Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes

Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes

Differences of Angiogenesis Factors in Tumor and Diabetes Mellitus

Identification and Verification of SLC27A1, PTBP1 and EIF5A With Significantly Altered Expression in Aggressive Pituitary Adenomas

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