Cell proliferation’ differentiation’ and apoptosis are modified by n−3 polyunsaturated fatty acids in normal colonic mucosa

Calviello, Gabriella; Palozza, Paola; Maggiano, Nicola; Piccioni, Elisabetta; Franceschelli, Piergiorgio; Frattucci, Andrea; Nicuolo, Fiorella Di; Bartoh, Gianna Maria

doi:10.1007/s11745-999-0404-6

Cited by 69 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oils containing high proportions of readily oxidizable n-3 PUFA could lower the oxidative stability of gut, which could predispose cell or tissue to free radical attack. The high level of n-3 PUFA seemed to cause negative effects for epithelial cells (Calviello et al, 1999) and even induced mucosa apoptosis (Courtney et al, 2007) and reduced the villous height in rats (Perin et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

Effects of dietary oil sources and calcium : phosphorus levels on growth performance, gut morphology and apparent digestibility of broiler chickens

Abdulla¹,

Loh²,

Akit³

et al. 2016

SA J. An. Sci.

View full text Add to dashboard Cite

The study investigated the effects of varying dietary calcium (Ca) levels and sources of oil on performance of broiler chickens. A total of 378 one-day-old birds were fed 6% palm oil (PO), soybean oil (SO) or linseed oil (LO) in combination with three levels of Ca, 1%, 1.25% and 1.5%, for six weeks in a 3 x 3 factorial experiment. Birds fed diet supplemented with SO and PO had higher average daily gains, more abdominal fat and greater villi height compared with those fed LO. However, feed efficiency, apparent digestibility of organic matter, ether extract, crude protein and ash were similar across treatments. Regardless of oil source, the chickens fed diets containing 1.5% Ca had a lower bodyweight and apparent digestibility of organic matter, crude protein, ether extract and phosphorus (P) than those fed 1% and 1.25% Ca. In contrast, the birds fed 1.25% Ca had higher ash, Ca and P digestibility than did the 1% Ca birds. Interaction between source of oil and Ca level on mineral digestibility was significant. It can be concluded that palm oil could be used as an alternative to soybean and linseed oils to improve growth performance in broiler chickens. Moreover, increasing the level of Ca to 1.25% can improve broiler performance and apparent nutrient digestibility, regardless of the type of oil used in the current study. ______________________________________________________________________________________

show abstract

Section: Resultsmentioning

confidence: 99%

Effects of dietary oil sources and calcium : phosphorus levels on growth performance, gut morphology and apparent digestibility of broiler chickens

Abdulla¹,

Loh²,

Akit³

et al. 2016

SA J. An. Sci.

View full text Add to dashboard Cite

show abstract

“…Omega-3 fatty acids have been shown to slow cell proliferation in normal tissues (Anti et al, 1994;Bartram et al, 1993;Calviello et al, 1999;Meydani et al, 1991) thus the observed reduction in the number of micronuclei in peripheral erythrocytes and in the number of apoptotic figures in the duodenal crypts of mice treated with CPT-11 and fed AAFA TM may simply be due to slower proliferation during the time of CPT-11 treatment. The fact that we observed less apoptosis in the crypt columns of the mice yet the number of cells in each crypt column was not changed also indicates that proliferation in the intestinal mucosa was slowed due to AAFA TM consumption.…”

Section: Experimental Therapeuticsmentioning

confidence: 99%

Consumption of an omega-3 fatty acids product, INCELL AAFA™, reduced side-effects of CPT-11 (irinotecan) in mice

2002

View full text Add to dashboard Cite

INCELL AAFATM , an omega-3 polyunsaturated fatty acid product containing a high concentration of long chain fatty acids, was tested for its ability to ameliorate the harmful side effects of CPT-11 chemotherapy including: leukopenia, anaemia, asthenia, weight loss and liver involvement. Four groups of mice were fed an AIN-76 diet modified to contain: 10% w/w corn oil (CO), 0% AAFA TM ; 9% CO, 1% AAFA TM ; 8% CO, 2% AAFA TM ; or 7% CO, 3% AAFA TM . After 2 weeks on the diets, half of the mice received CPT-11 chemotherapy (60 mg kg 71 q 4 days, i.v.) the rest of the mice received vehicle for 2 weeks. It was found that 2% AAFA TM in the diet of the CPT-11 treated mice: decreased apoptotic figures in the duodenal crypts; markedly suppressed the inflammatory eicosanoid, prostaglandin E 2 in the liver; prevented liver hypertrophy; improved white blood cell counts; significantly increased red blood cell counts; decreased numbers of CPT-11 induced immature red blood cell and micronuclei in red blood cells of the peripheral blood; increased eicosapentaenoic acid and docosahexaenoic acid in liver cell membranes and maintained normal grooming behaviour. Thus 2% AAFA TM in the diet reduced the side effects of CPT-11 treatment in mice.

show abstract

“…[5][6][7][8][9][10][11][12][13][14] A number of studies have indicated that DHA's anticancer properties are not directly due to cytotoxicity but rather to the fatty acid's ability to induce apoptosis. [15][16][17][18] However, the molecular mechanism for the anticancer actions of omega-3 fatty acids remains unknown. Understanding the mechanistic effects of omega-3 lipids may aid in the development of new cancer therapies.…”

mentioning

confidence: 99%

Omega‐3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase‐mediated pathway

Harvey

Ruzmetov

et al. 2005

Intl Journal of Cancer

118

View full text Add to dashboard Cite

The effect of fish oils and their active omega-3 fatty acid constituents, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), were investigated on breast cancer growth. In in vivo experiments, mice were fed diets that were rich in either omega-3 (fish oil) or omega-6 (corn oil) fatty acids. Three weeks after implantation of MDA-MB-231 breast cancer cells, the tumor volume and weight were significantly lower (p < 0.05) for mice fed the omega-3 diets compared to those fed the omega-6 diets. Dietary fish oil also caused a 40% (p < 0.05) increase in neutral sphingomyelinase (N-SMYase) activity in the tumors. The tumor tissues from fish oil-fed animals expressed elevated p21 (waf1/cip1) mRNA, whereas tumor tissues from corn oil-fed animals exhibited undetectable levels of p21 expression. In in vitro experiments, at concentrations as low as 25 mM, DHA and EPA inhibited the growth of cultured MDA-MB-231 cells in a dose-dependent manner by 20-25% (p < 0.05). N-SMYase activity was also increased by 30-40% (p < 0.05) in the DHA-or EPA-treated cells in which an increase in ceramide formation was observed. DHA and EPA were both observed to enhance membrane bleb formation and also to induce the expression of p21. Omega-3 fatty acids-induced bleb formation and p21 expression were inhibited by the N-SMYase inhibitor GW4869, which also inhibited apoptosis by approximately 40% (p < 0.05). The results suggest that inhibition of breast cancer growth in nude mice by dietary fish oil and inhibition of breast cancer cell growth in culture by treatment with DHA and EPA is mediated by activation of N-SMYase. ' 2005 Wiley-Liss, Inc.

show abstract

Cell proliferation’ differentiation’ and apoptosis are modified by n−3 polyunsaturated fatty acids in normal colonic mucosa

Cited by 69 publications

References 28 publications

Effects of dietary oil sources and calcium : phosphorus levels on growth performance, gut morphology and apparent digestibility of broiler chickens

Effects of dietary oil sources and calcium : phosphorus levels on growth performance, gut morphology and apparent digestibility of broiler chickens

Consumption of an omega-3 fatty acids product, INCELL AAFA™, reduced side-effects of CPT-11 (irinotecan) in mice

Omega‐3 polyunsaturated fatty acids attenuate breast cancer growth through activation of a neutral sphingomyelinase‐mediated pathway

Contact Info

Product

Resources

About