1992
DOI: 10.1007/bf01208614
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Cell proliferation in human tumours growing in nude mice: renal cell carcinomas, larynx and hypopharynx carcinomas

Abstract: Cell proliferation of 51 human renal cell carcinomas and 9 larynx and hypopharynx carcinomas has been studied in vitro and using xenotransplants. The proliferative activity ([3H]thymidine labelling index) increases during the first passages in nude mice and then remains almost constant throughout subsequent passages. A comparison of cell kinetic parameters of 8 human renal cell carcinomas, 1 hypopharynx and 2 larynx carcinomas, with data of xenografts and of human tumours in situ published up to now, shows tha… Show more

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Cited by 5 publications
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“…Second, RCC is seldom treated with chemotherapy, and thus, the molecular genetics and behavior of the tumor is unlikely to be affected by previous exposure to DNA damaging agents. Third, RCCs implanted in mice preserve the histology and karyotype of patient tumors (10)(11)(12)(13)(14)(15)(16). Fourth, the implantation of tumors heterotopically in mice may affect tumor biology (17)(18)(19), but the site for orthotopic implantation of RCC, under the kidney capsule, is a privileged site for tumor growth (4).…”
Section: Introductionmentioning
confidence: 99%
“…Second, RCC is seldom treated with chemotherapy, and thus, the molecular genetics and behavior of the tumor is unlikely to be affected by previous exposure to DNA damaging agents. Third, RCCs implanted in mice preserve the histology and karyotype of patient tumors (10)(11)(12)(13)(14)(15)(16). Fourth, the implantation of tumors heterotopically in mice may affect tumor biology (17)(18)(19), but the site for orthotopic implantation of RCC, under the kidney capsule, is a privileged site for tumor growth (4).…”
Section: Introductionmentioning
confidence: 99%