Cell proliferation kinetics in human solid tumors: relation to probability of metastatic dissemination and long-term survival

Tubiana, M; Courdi, A.

doi:10.1016/0167-8140(89)90113-8

Cited by 166 publications

(83 citation statements)

References 91 publications

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“…Most recently, Bouzubar et al (1989) have demonstrated mitotic activity. Many studies have now confirmed the adverse prognosis associated with cancers which have a high proliferative status, and the proliferative rate is generally held to be higher in metastases than in primary tumours of the same histology (Tubiana & Courdi, 1989). In their study of the relationship of ploidy status, TFR and EGFR reactivity in breast cancer patients, Walker and Camplejohn (1986) demonstrated significant relationships between (a) DNA ploidy and percentage S-phase cells, (b) the degree of histologic differentiation and S-phase content and (c) the degree of TFR and EGFR expression and both ploidy status and S-phase fraction.…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Table I (Tubiana & Courdi, 1989). Proliferative status has been most commonly studied in patients with breast cancer for whom it can be shown that a high proliferative rate is strongly linked not only to a short relapse-free and overall survival , but also to other conventional prognostic factors such as poor histological grade, oestrogen receptor negativity and DNA aneuploidy (McGurrin et al, 1987;Wrba et al, 1989).…”

Section: Immunohistochemistrymentioning

confidence: 99%

“…Estimation of the labelling index (LI) by in vitro incorporation by tumour fragments of tritiated thymidine has been a reliable, albeit long and tedious, technique which has yielded important information in many types of cancer, confirming the clinical wisdom that fast growing cancers are more rapidly fatal than slowly growing ones (Tubiana & Courdi, 1989). For patients with breast cancer, it has been suggested that the number of mitotic figures present is the most important prognostic variable .…”

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confidence: 99%

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An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers

Furlong²,

Cooke³

et al. 1990

Br J Cancer

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Section: Immunohistochemistrymentioning

confidence: 99%

Section: Immunohistochemistrymentioning

confidence: 99%

mentioning

confidence: 99%

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An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers

Furlong²,

Cooke³

et al. 1990

Br J Cancer

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“…The proliferation rate has been related to survival prediction (Murray and Kirschner, 1989;Pardee, 1989) and tumour cell kinetics studies have indicated a relationship between high cell proliferation rates and tumour aggressiveness (Tubiana and Courdi, 1989). Ki-67, a nonhistone protein, is a DNA-binding nuclear protein expressed throughout the cell cycle in proliferating cells, but not in quiescent (G 0 ) cells.…”

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confidence: 99%

Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis

et al. 2004

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Among new biological markers that could become useful prognostic factors for lung carcinoma, Ki-67 is a nuclear protein involved in cell proliferation regulation. Some studies have suggested an association between Ki-67 and poor survival in lung cancer patients. In order to clarify this point, we have performed a systematic review of the literature, using the methodology already described by our Group, the European Lung Cancer Working Party. In total, 37 studies, including 3983 patients, were found to be eligible. In total, 49% of the patients were considered as having a tumour positive for the expression of Ki-67 according to the authors cutoff. In all, 29 of the studies dealt with non-small-cell lung carcinoma (NSCLC), one with small-cell carcinoma (SCLC), two with carcinoid tumours and five with any histology. In terms of survival results, Ki-67 was a bad prognosis factor for survival in 15 studies while it was not in 22. As there was no statistical difference in quality scores between the significant and nonsignificant studies evaluable for the meta-analysis, we were allowed to aggregate the survival results. The combined hazard ratio for NSCLC, calculated using a random-effects model was 1.56 (95% CI: 1.30 -1.87), showing a worse survival when Ki-67 expression is increased. In conclusion, our meta-analysis shows that the expression of Ki-67 is a factor of poor prognosis for survival in NSCLC.

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“…Cell proliferation is also seen as a fundamental biologic mechanism in oncogenesis 8 and in the detection of cell growth fraction markers such as antibody Ki-67, used as a prognostic factor in a wide variety of tumors [9][10][11] .…”

Section: Introductionmentioning

confidence: 99%

Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

Rodrigues

Motta

Machado

et al. 2008

Rev. Bras. Otorrinolaringol.

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Prognost ic histological factors may contribute to determine the evolution of this neoplasia. Aim: To correlate p53 and Ki-67 immunohistochemical expression with age, histological degree, lymph node involvement and pathological staging in patients with laryngeal epidermoid carcinomas. Methods:We assessed thirty consecutive cases of laryngeal epidermoid carcinomas submitted to immunohistochemistry to check the expression of p53 e Ki-67 antibodies. Results: Mean age was of 56.2 years and the immunoexpression of the markers was observed in the group with more than 50 years of age, especially that o the ki-67 antibody (p=0.032). There was no relation between p53 and Ki-67 with lymph node involvement. Ki-67 was expressed in 70% of the high histology level cases and in 80% in the low histology ones; while p53 was of 70% only in the high level cases. Pathology staging showed that in the group of advanced carcinomas, p53 expression was of 61.5%, while Ki-67 proved positive for the early cases (100%) and advanced (73.1%). Conclusion: There were no significant differences between p53 and Ki-67 immunoexpression in laryngeal epidermoid carcinoma, except in the group of patients with more than 50 years of age, when Ki-67 expression was significantly higher.

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Cell proliferation kinetics in human solid tumors: relation to probability of metastatic dissemination and long-term survival

Cited by 166 publications

References 91 publications

An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers

An immunohistochemical assessment of cellular proliferation markers in head and neck squamous cell cancers

Ki-67 expression and patients survival in lung cancer: systematic review of the literature with meta-analysis

Valor prognóstico da correlação imunoistoquímica do Ki-67 e p53 em carcinomas epidermóides da laringe

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