Cell replacement therapy is the remedial solution for treating Parkinson’s disease

Venkatesan, Dhivya; Vellingiri, Balachandar

doi:10.21037/sci.2017.06.08

Cited by 18 publications

(8 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the recent advances in the technology of stem cell therapy, ESCs, NPCs, and induced neural stem cells have been used to treat neurodegenerative diseases 50 , 51 . As regenerative resources, the use of NPCs requires sufficient proliferation and appropriate differentiation.…”

Section: Discussionmentioning

confidence: 99%

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

et al. 2018

View full text Add to dashboard Cite

Sox2 is a key transcriptional factor for maintaining pluripotency of stem cells. Sox2 deficiency causes neurodegeneration and impairs neurogenesis. Although the transcriptional regulation of Sox2 has been extensively studied, the mechanisms that control Sox2 protein turnover are yet to be clarified. Here we show that the RING-finger ubiquitin ligase complex CUL4ADET1-COP1 and the deubiquitylase OTUD7B govern Sox2 protein stability during neural progenitor cells (NPCs) differentiation. Sox2 expression declines concordantly with OTUD7B and reciprocally with CUL4A and COP1 levels upon NPCs differentiation. COP1, as the substrate receptor, interacts directly with and ubiquitylates Sox2, while OTUD7B removes polyUb conjugates from Sox2 and increases its stability. COP1 knockdown stabilizes Sox2 and prevents differentiation, while OTUD7B knockdown destabilizes Sox2 and induces differentiation. Thus, CUL4ADET1-COP1 and OTUD7B exert opposite roles in regulating Sox2 protein stability at the post-translational level, which represents a critical regulatory mechanism involved in the maintenance and differentiation of NPCs.

show abstract

Section: Discussionmentioning

confidence: 99%

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Fetal brain tissue can be used for cell replacement therapy in neurodegenerative diseases, such as Parkinson's disease, but it is limited by donor deficiency and cannot be standardized (67). Fortunately, the induced differentiation into specific cell groups after the expansion of NSCs in vitro can solve this problem.…”

Section: Related Biological Processes Of Brn4mentioning

confidence: 99%

Research progress of the transcription factor Brn4 (Review)

Zhang

Wang

et al. 2020

Mol Med Rep

View full text Add to dashboard Cite

“…For this reason, the use of stem cells in infertility treatment may come to debate soon. [20][21][22][23][24]…”

Section: Embryonic Stem Cells Treatment and Therapymentioning

confidence: 99%

Stem Cells and Regenerative Medicine

Hayretdag¹,

Çoşkunpınar²

2019

Turk J Immunol

View full text Add to dashboard Cite

Stem cells are self-renewing, non-differentiated cells that can be transforming into many different cell types and can form all the tissues and organs in our body when proper conditions are provided. Stem cells can be divided into three groups: adult stem cells, stem cells derived from cord blood, and embryonic stem cells. These cells, which have not yet differentiated, have the capacity of self-renewal, unlimited division and can transform into organs and tissues. Adult stem cells are found in many tissues and organs in the body and when damage occurs they multiply at that position to repair the damaged area. Discovery of stem cell differentiation also opened the doors for stem cell therapy in different fields such as; cancer, paralysis, Alzheimer's, parkinsonism, spinal cord injuries, heart diseases and many genetic diseases. ÖzKök hücreler, çok farklı hücre tiplerine dönüşebilen ve uygun koşullar sağlandığında vücudumuzdaki tüm doku ve organları oluşturabilen, kendini yenileyebilen, farklılaşmamış hücrelerdir. Kök hücreler üç gruba ayrılabilir: yetişkin kök hücreler, kord kanından elde edilen kök hücreler ve embriyonik kök hücreler. Henüz farklılaşmamış bu hücreler, kendini yenileme, sınırsız bölünme kapasitesine sahiptir ve organlara ve dokulara dönüşebilirler. Yetişkin kök hücreler, vücuttaki birçok doku ve organda bulunur ve hasar meydana geldiğinde hasarlı alanı onarmak için bu pozisyonda çoğalırlar. Kök hücre farklılaşmasının keşfi, kanser, felç, Alzheimer, parkinsonizm, omurilik yaralanmaları, kalp hastalıkları ve birçok genetik hastalık gibi farklı alanlarda kök hücre tedavisi için kapılar açmıştır.Anahtar Kelimeler: Kök hücre, rejeneratif tıp, kişiselleştirilmiş tıp Stem cellStem cells are cells that have the potential to replace the cells lost in the life of the organism in the embryonic and adulthood with the effect of environmental signals and transform into different cell types. [1,2]

show abstract

Cell replacement therapy is the remedial solution for treating Parkinson’s disease

Cited by 18 publications

References 76 publications

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Research progress of the transcription factor Brn4 (Review)

Stem Cells and Regenerative Medicine

Contact Info

Product

Resources

About