2023
DOI: 10.3390/vaccines11030525
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Cell Surface Fibroblast Activation Protein-2 (Fap2) of Fusobacterium nucleatum as a Vaccine Candidate for Therapeutic Intervention of Human Colorectal Cancer: An Immunoinformatics Approach

Abstract: Colorectal cancer (CRC) is one of the most common cancers and is the second-highest in cancer-related deaths worldwide. The changes in gut homeostasis and microbial dysbiosis lead to the initiation of the tumorigenesis process. Several pathogenic gram-negative bacteria including Fusobacterium nucleatum are the principal contributors to the induction and pathogenesis of CRC. Thus, inhibiting the growth and survival of these pathogens can be a useful intervention strategy. Fibroblast activation protein-2 (Fap2) … Show more

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Cited by 19 publications
(13 citation statements)
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“…The RMSF analysis provided the valuable insights into the dynamic behavior of the complex, which could aid in optimizing the vaccine design and enhancing its efficacy. The generated findings were consistent with earlier research ( Padma et al., 2023 ), which emphasized the importance of flexibility in interactions. Therefore, the RMSF analysis presented the significance of flexibility in the design of effective vaccines.…”
Section: Resultssupporting
confidence: 92%
“…The RMSF analysis provided the valuable insights into the dynamic behavior of the complex, which could aid in optimizing the vaccine design and enhancing its efficacy. The generated findings were consistent with earlier research ( Padma et al., 2023 ), which emphasized the importance of flexibility in interactions. Therefore, the RMSF analysis presented the significance of flexibility in the design of effective vaccines.…”
Section: Resultssupporting
confidence: 92%
“…Several studies have reported that alterations in gut microbial homeostasis as well as pathogenic bacteria may trigger the oncogenic process of colorectal cancer (CRC). Among them, F. nucleatum is considered to be one of the pathogenic bacteria that induce CRC in humans 27 . Previous studies in our laboratory also found increased abundance of Firmicutes and Proteobacteria in mice infected with E. granulosus compared to the normal group 28 …”
Section: Introductionmentioning
confidence: 53%
“…Among them, F. nucleatum is considered to be one of the pathogenic bacteria that induce CRC in humans. 27 Previous studies in our laboratory also found increased abundance of Firmicutes and Proteobacteria in mice infected with E. granulosus compared to the normal group. 28 Over the past few years, several studies have focused on the relationship between parasitic infections and the gut microbiota, showing that parasitic infections affect the composition of the host gut flora, while the gut flora also affects the viability and infectivity of the parasite.…”
Section: Introductionmentioning
confidence: 55%
“…It has been reported that tumor microbiota vaccine targeting F. nucleatum have the latent capacity to ameliorate the prognosis of CRC 22 . Fibroblast activating protein 2 (Fap2) is an essential membrane protein for F. nucleatum that can encourage bacterial adhesion to colon cells, recruit immune cells, and lead to tumor development, and designing a vaccine candidate containing Fap2 B‐ and T‐cell epitopes may serve as a promising therapeutic approach to intervene in F. nucleatum ‐induced human CRC 23 . Metronidazole (MNZ) is a pivotal drug for a variety of infections, which are induced by anaerobic bacteria, besides, MTZ reduced cell viability of DLD‐1 cell lines 24 .…”
Section: Introductionmentioning
confidence: 99%