Cell technologies in the treatment of rheumatic diseases

Soroka, N.; Потапнев, М. П.; Мартусевич, Н. А.

doi:10.14412/1995-4484-2019-685-692

Naučno-praktičeskaâ revmatologiâ

2019

DOI: 10.14412/1995-4484-2019-685-692

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Cell technologies in the treatment of rheumatic diseases

N. Soroka

М. П. Потапнев

Н. А. Мартусевич

Abstract: П р о г р е с с в р е в м а т о л о г и и в X X I в е к е Сорока Н.Ф.заведующий 2-й кафедрой внутренних болезней УО «Белорусский государственный медицинский университет», профессор, докт. мед. наук 1 УО «Белорусский государственный медицинский университет», Минск, Беларусь; 2 ГУ «Республиканский научно-практический центр трансфузиологии и медицинских биотехнологий»,

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References 51 publications

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Influence of Peloid Therapy on the Condition and Functional Activity of the Glands of Internal Secretion in Juvenile Rheumatoid Arthritis (Clinical and Experimental Study)

Каладзе

Zyablitskaya

2020

Bulletin of Restorative Medicine

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The aim of the study was to assess the dynamics of hormones of the pituitary-gonadal-thyroid axis in patients with juvenile rheumatoid arthritis under the influence of peloid therapy and to establish the corresponding morphological changes in the pituitary gland, gonads and the thyroid gland of white Wistar rats with induced adjuvant arthritis during peloid therapy. Material and methods. 46 patients with juvenile rheumatoid arthritis were examined during their rehabilitation at sanatoria. The effect of peloid therapy on the pituitary-gonadal-thyroid axis was evaluated based on the changes in the levels of the main hormones LH, FSH, estradiol, testosterone, TSH, T3, T4. The control group consisted of 15 healthy age-mates. Morphological changes in the pituitary, testes, ovaries and thyroid gland were studied in 24 white Wistar rats with adjuvant arthritis. Results. In juvenile rheumatoid arthritis, the pituitary-gonad-thyroid axis is activated, which is manifested by a decrease in the production of FSH, LH, TSH, testosterone in boys of all age groups and estradiol both in girls regardless of their age and in boys 12–17 years of age. At the same time, an increase in secretion of T3, T4 was observed. The most pronounced deviations were noted in patients with a systemic form of the disease, with a high degree of severity and duration of the disease. The inclusion of mud therapy into the program of sanatorium rehabilitation leads to positive changes in the levels of the studied hormones. The experiment with induced adjuvant arthritis revealed reversible ultrastructural and tinctorial changes in the thyrotropocytes and gonadotropocytes of the pituitary gland, as well as impaired differentiation and partial destruction of the structural elements in the thyroid gland and gonads. The course of peloid therapy had a positive effect on the condition of the thyroid gland and gonads in the experimental animals, which was manifested by the restoration of structural and functional organization. Conclusion. Peloid therapy has a positive effect on the functional activity of the pituitary-gonadal thyroid axis in patients with juvenile rheumatoid arthritis, which has been confirmed by experimental data.

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Influence of Peloid Therapy on the Condition and Functional Activity of the Glands of Internal Secretion in Juvenile Rheumatoid Arthritis (Clinical and Experimental Study)

Каладзе

Zyablitskaya

2020

Bulletin of Restorative Medicine

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The Influence of Sanatorium-Resort Rehabilitation on the Cytokine Profile and Quality of Life Parameters in Juvenile Rheumatoid Arthritis

Soboleva

Каладзе

2021

Bulletin of Rehabilitation Medicine

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Aim. To study was to assess the dynamics of cytokine profile indicators and quality of life in patients with juvenile rheumatoid arthritis under the influence of the standard sanatorium-resort rehabilitation complex. Material and methods. At the stage of sanatorium rehabilitation, 112 patients aged from 8 to 17 years (mean age 13.2±3.7) with juvenile rheumatoid arthritis were examined. The dynamics of the main quality of life indicators were assessed using the CHAQ questionnaire (pediatric version). Changes in proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory cytokines (IL-4, IL-10) were evaluated in correlation with quality of life indices. The control group consisted of 25 healthy equals in age. Results. In juvenile rheumatoid arthritis, the cytokine profile changes, expressed in significantly higher indices of both pro- and antiinflammatory cytokines associated with functional disorders and, as a consequence, lower quality of life indicators as compared with healthy equals in age. Under the influence of sanatorium-resort treatment, functional disorders decreased, quality of life increased, levels of TNF-α, IL-1 as well as anti-inflammatory cytokine IL-4 significantly (p<0,05) decreased. As for other both pro- and antiinflammatory cytokines, only non-significant tendency to decrease was registered. Conclusion. It has been established that before the beginning of sanatorium-resort treatment, the quality of life parameters were lower in patients with juvenile rheumatoid arthritis (JRA), while the values of both proinflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines were significantly (p<0,01) higher than in the control group. At the same time, changes in the studied parameters correlated with the activity of the inflammatory process and the severity of the functional insufficiency of the joints. There were noted the positive influence of the standard complex of sanatorium-resort treatment on the examined quality of life parameters and the tendency to normalization of cytokine profile indexes in patients with JRA.

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Cell technologies in the treatment of rheumatic diseases

Cited by 2 publications

References 51 publications

Influence of Peloid Therapy on the Condition and Functional Activity of the Glands of Internal Secretion in Juvenile Rheumatoid Arthritis (Clinical and Experimental Study)

Influence of Peloid Therapy on the Condition and Functional Activity of the Glands of Internal Secretion in Juvenile Rheumatoid Arthritis (Clinical and Experimental Study)

The Influence of Sanatorium-Resort Rehabilitation on the Cytokine Profile and Quality of Life Parameters in Juvenile Rheumatoid Arthritis

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