Cell Therapy: In Vitro Topographical Model of Fuchs Dystrophy for Evaluation of Corneal Endothelial Cell Monolayer Formation (Adv. Healthcare Mater. 22/2016)

Abstract

Micro‐structural changes in the corneal endothelial basement membrane cause Fuchs dystrophy, which leads to corneal blindness. On page 2896, Muhammad Rizwan and co‐workers demonstrate a micro‐fabricated in vitro disease model of Fuchs dystrophy by recapitulating the topographical details of diseased basement membrane. This model is employed to elucidate complex interaction of corneal cells with the disease‐like surface to study corneal endothelial monolayer reformation for the development of corneal cell regenerative therapies.