Cell Type-specific Study to Unveil the Relation Between DLBCL and GBM Through Blood-Brain-Barrier Disruption

Abstract

Diffuse large B cell lymphoma is an aggressive and fast-growing form of non-Hodgkin’s lymphoma. DLBCL becomes fatal if it is not treated in the early stage. Despite its aggressive nature, ~50-70\% patients respond successfully, whereas ~30-40\% patients have an inadequate response to the currently available therapies. DLBCL spread to the brain through spinal fluid. It is becoming a rapid emergency to detect the cell-specific changes of DLBCL metastasis that leads to central nervous system (CNS) disorder. As per our knowledge, the cell-specific studies of genes of DLBCL involved in CNS disorder are still limited. To bridge this gap, we proposed a novel analysis. Firstly, we have identified DLBCL cell-specific gene clusters and considered genes along with their associated pathways that have an impact on blood-brain-barrier disruption. In the second stage, we tried to establish the relation between Diffuse large B cell lymphoma and glioblastoma based on cell-specific pathways. Interestingly it has been observed that high semantic-valued pathways are the prime regulators of GBM. Finally, this study reveals how cell types are responsible for the pathway shifts and also provides a cell-specific channel of triggering the progression of GBM among DLBCL patients.