Cell type specificity of lung cancer associated with nitric oxide

Liaw, Yung‐Po; Ting, Tih-Fen; Ho, Chien-Chang; Chiou, Ze-Ying

doi:10.1016/j.scitotenv.2010.06.023

Cited by 12 publications

(14 citation statements)

References 28 publications

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“…This is consistent with our previous paper which showed that the air pollutants NO [8] are positive significant association with incidence of AC in Taiwan. To the best of our knowledge, this ecological study was the first to focus on the relationship between cell type specificity of female lung cancer and SO 2 from outdoor air pollution by using the cancer register data from 2001 to 2005 in Taiwan.…”

Section: Discussionsupporting

confidence: 93%

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Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study

Tseng

Huang

et al. 2012

BMC Public Health

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BackgroundMany studies have examined the association between air pollutants (including sulfur dioxide [SO2], carbon monoxide [CO], nitrogen dioxide [NO2], nitric oxide [NO], ozone [O3], and particulate matter < 10 μm [PM10]) and lung cancer. However, data from previous studies on pathological cell types were limited, especially for SO2 exposure. We aimed to explore the association between SO2 exposure from outdoor air pollutants and female lung cancer incidence by cell type specificity.MethodsWe conducted an ecological study and calculated annual average concentration of 6 air pollutants (SO2, CO, NO2, NO, O3, and PM10) using data from Taiwan Environmental Protection Administration air quality monitoring stations. The Poisson regression models were used to evaluate the association between SO2 and age-standardized incidence rate of female lung cancer by two major pathological types (adenocarcinoma [AC] and squamous cell carcinoma [SCC]). In order to understand whether there is a dose-response relationship between SO2 and two major pathological types, we analyzed 4 levels of exposure based on quartiles of concentration of SO2.ResultsThe Poisson regression results showed that with the first quartile of SO2 concentration as the baseline, the relative risks for AC/SCC type cancer among females were 1.20 (95% confidence interval [CI], 1.04-1.37)/1.39 (95% CI, 0.96-2.01) for the second, 1.22 (95% CI, 1.04-1.43)/1.58 (95% CI, 1.06-2.37) for the third, and 1.27 (95% CI, 1.06-1.52)/1.80 (95% CI, 1.15-2.84) for the fourth quartile of SO2 concentration. The tests for trend were statistically significant for both AC and SCC at P = 0.0272 and 0.0145, respectively.ConclusionThe current study suggests that SO2 exposure as an air pollutant may increase female lung cancer incidence and the associations with female lung cancer is much stronger for SCC than for AC. The findings of this study warrant further investigation on the role of SO2 in the etiology of SCC.

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Section: Discussionsupporting

confidence: 93%

“…It seems that risk factors other than smoking may play a more important role in the pathogenesis of female lung cancer. Our previous results showed that the air pollutants CO [7] and NO [8] had a positive significant association with incidence of lung adenocarcinoma (AC) in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

Cell type specificity of female lung cancer associated with sulfur dioxide from air pollutants in Taiwan: An ecological study

Tseng

Huang

et al. 2012

BMC Public Health

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“…Air pollution exposure misclassification is a particular concern, due to the long latency period for lung cancer, temporal changes in air pollution levels, and the likelihood of substantial residential mobility during biologically relevant exposure periods. 9,10 In addition, little research has examined air pollution exposure and lung cancer risk by histological subtypes, [11][12][13][14] due to the need for large sample sizes. 9,10 In addition, little research has examined air pollution exposure and lung cancer risk by histological subtypes, [11][12][13][14] due to the need for large sample sizes.…”

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confidence: 99%

Long-term Residential Exposure to Air Pollution and Lung Cancer Risk

et al. 2013

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“…Studies have been shown that women had particularly large effects for lung cancer in the young age group, somewhat less so for the old exposed to nitrogen oxide (Naess et al, 2007). Moreover NOx exposure has significant correlations with adenocarcinoma (AC) type cancer incidence rates for both genders , although women seem to be more susceptible (Liaw et al, 2010). NOx may potentially trigger mutagenic and carcinogenic activity and play significant roles in the metabolism and behavior of AC type lung cancer (Fujimoto et al, 1998).…”

Section: Carcinogenic and Mutagenic Effectsmentioning

confidence: 99%

“…Moreover, recent results have shown that NO stimulates p53 accumulation (Forrester et al, 1996). In summary, according to previous literature, NO and its derivatives can cause DNA damages (Wink et al, 1993) and play important roles in human lung AC (Fujimoto et al,1998) (Liaw et al, 2010). Airborne polycyclic aromatic hydrocarbons (PAHs) are emitted when organic matter is burned.…”

Section: Carcinogenic and Mutagenic Effectsmentioning

confidence: 99%