Cella Media Distance in Human Brain in Relation to Age and Gender

Ragan, Lydia; Waczulı́ková, Iveta; Guller, Ladislav; Bilicky, J.; Benuska, J

doi:10.5507/bp.2009.053

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…In human intersex differences are presented and show a lower ventricular volume in female subjects than in male ones [28]. It would be interesting to assess whether these anatomical differences based on the age and sex of the subject also occur in a similar way in the sheep animal model.…”

Section: Discussionmentioning

confidence: 97%

Morphometric study of the ventricular indexes in healthy ovine BRAIN using MRI

et al. 2022

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Background Sheep (Ovis aries) have been largely used as animal models in a multitude of specialties in biomedical research. The similarity to human brain anatomy in terms of brain size, skull features, and gyrification index, gives to ovine as a large animal model a better translational value than small animal models in neuroscience. Despite this evidence and the availability of advanced imaging techniques, morphometric brain studies are lacking. We herein present the morphometric ovine brain indexes and anatomical measures developed by two observers in a double-blinded study and validated via an intra- and inter-observer analysis. Results For this retrospective study, T1-weighted Magnetic Resonance Imaging (MRI) scans were performed at 1.5 T on 15 sheep, under general anaesthesia. The animals were female Ovis aries, in the age of 18-24 months. Two observers assessed the scans, twice time each. The statistical analysis of intra-observer and inter-observer agreement was obtained via the Bland-Altman plot and Spearman rank correlation test. The results are as follows (mean ± Standard deviation): Indexes: Bifrontal 0,338 ± 0,032 cm; Bicaudate 0,080 ± 0,012 cm; Evans’ 0,218 ± 0,035 cm; Ventricular 0,241 ± 0,039 cm; Huckman 1693 ± 0,174 cm; Cella Media 0,096 ± 0,037 cm; Third ventricle ratio 0,040 ± 0,007 cm. Anatomical measures: Fourth ventricle length 0,295 ± 0,073 cm; Fourth ventricle width 0,344 ± 0,074 cm; Left lateral ventricle 4175 ± 0,275 cm; Right lateral ventricle 4182 ± 0,269 cm; Frontal horn length 1795 ± 0,303 cm; Interventricular foramen left 1794 ± 0,301 cm; Interventricular foramen right 1,78 ± 0,317 cm. Conclusions The present study provides baseline values of linear indexes of the ventricles in the ovine models. The acquisition of these data contributes to filling the knowledge void on important anatomical and morphological features of the sheep brain.

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Section: Discussionmentioning

confidence: 97%

Morphometric study of the ventricular indexes in healthy ovine BRAIN using MRI

et al. 2022

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“…Healthy head layers thickness have been adopted from the literature as presented on Fig. 1 [26], [27].…”

Section: Methodsmentioning

confidence: 99%

Brain Light-Tissue Interaction Modelling: Towards a non-invasive sensor for Traumatic Brain Injury

Roldán

Chatterjee

Kyriacou

2021

2021 43rd Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Traumatic brain injury (TBI) is one of the leading causes of death worldwide, yet there is no systematic approach to monitor TBI non-invasively. To the aim of developing a novel optical sensor for TBI monitoring, this paper presents a Monte Carlo model of optical interaction with healthy human head to optimize the sensor geometry. Investigation with a range of source-detector separations at a near-infrared optical window reveals that maximum light is absorbed in the skull and the minimum interaction takes place in the subarachnoidal space. Such information will be helpful to the next step of modelling with neurocritical brain tissue followed by the sensor development.

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