Cellular and Molecular Aspects of Short-Term and Long-Term Memory from Molluscan Systems

Iwase, Masao; Okajima, Shoji; Takahashi, Rei; Mogami, Tamiko; Kusaka, Nahoko; Kuratsune, Hirohiko; Takeda, Masatoshi; Shimizu, Akira

doi:10.1007/978-4-431-73464-2_8

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…Drosophila, Aplysia , Lymnaea , Apis ) preparations have demonstrated that ‘spaced’ training results in a longer lasting LTM than does ‘massed’ learning [17–23]. We have previously shown in Lymnaea that spaced or distributed training was more effective than massed training in both classical conditioning [24,25] and operant conditioning [21]. Here we determined whether spaced training was also more effective than massed training to result in enhanced memory in TAC.…”

Section: Introductionmentioning

confidence: 99%

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

et al. 2013

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The present study investigated the optimal training procedure leading to long-lasting taste avoidance behavior in Lymnaea. A training procedure comprising 5 repeated pairings of a conditional stimulus (CS, sucrose), with an unconditional stimulus (US, a tactile stimulation to the animal’s head), over a 4-day period resulted in an enhanced memory formation than 10 CS-US repeated pairings over a 2-day period or 20 CS-US repeated pairings on a single day. Backward conditioning (US-CS) pairings did not result in conditioning. Thus, this taste avoidance conditioning was CS-US pairing specific. Food avoidance behavior was not observed following training, however, if snails were immediately subjected to a cold-block (4°C for 10 min). It was critical that the cold-block be applied within 10 min to block long-term memory (LTM) formation. Further, exposure to the cold-block 180 min after training also blocked both STM and LTM formation. The effects of the cold-block on subsequent learning and memory formation were also examined. We found no long lasting effects of the cold-block on subsequent memory formation. If protein kinase C was activated before the conditioning paradigm, snails could still acquire STM despite exposure to the cold-block.

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Section: Introductionmentioning

confidence: 99%

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

et al. 2013

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“…Lymnaea stagnalis is also capable of visuovestibular conditioning (VVC) and taste-aversion conditioning, which both involve portions of the whole-animal withdrawal response that is mediated in part by the Right Pedal Dorsal 11 (RPeD11) neuron (Ferguson and Benjamin, 1991a;Ferguson and Benjamin, 1991b;Inoue et al, 1996b;Kawai et al, 2004;Sakakibara, 2006;Sakakibara, 2008;Sakakibara et al, 1998;Syed and Winlow, 1991). RPeD11 also appears to play a role in the stressenhanced operant conditioning training procedure of aerial respiration that leads to LTM (Martens et al, 2007a;Martens et al, 2007b;Sunada et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

The shadow-induced withdrawal response, dermal photoreceptors, and their input to the higher-order interneuron RPeD11 in the pond snailLymnaea stagnalis

Sunada

Sakaguchi

Horikoshi

et al. 2010

Journal of Experimental Biology

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SUMMARYThe shadow-induced withdrawal response in Lymnaea stagnalis is mediated by dermal photoreceptors located on the foot, mantle cavity, and skin around the pneumostome area. Here, we determined whether we could obtain a neural correlate of the withdrawal response elicited by a shadow in a higher-order central neuron that mediates withdrawal behavior. We measured the electrophysiological properties of the higher-order interneuron Right Pedal Dorsal 11 (RPeD11), which has a major role in Lymnaea withdrawal behavior. In semi-intact preparations comprising the circumesophageal ganglia, the mantle cavity and the pneumostome, but not the foot and eyes, a light-on stimulus elicited a small short-lasting hyperpolarization and a light-off stimulus elicited a depolarization of RPeD11. We also determined that dermal photoreceptors make a monosynaptic contact with RPeD11. The dermal photoreceptor afferents course to the circumesophageal ganglia via the anal and genital nerves to the visceral ganglion, and/or via the right internal and external parietal nerves to the parietal ganglion. Finally, in addition to responding to photic stimuli, RPeD11 responds to both mechanical and chemical stimuli delivered to the pneumostome.

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“…It is important to emphasize that different mechanisms underpin these memory types. Short-term memory depends on changes in the synaptic strength of pre-existing neuronal connections, driven by modi cations of pre-existing proteins [57].…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, long-term memory formation relies on the synthesis of new proteins and morphological modi cations [57]. Differentiation between short-, intermediate-, and long-term memory also hinges on the involvement of various signaling proteins [58,59], distinct stages of gene expression [60], neuronal activity [61] and synaptic plasticity (early and late LTP) [62].…”

Section: Discussionmentioning

confidence: 99%

HBK-15, a multimodal compound, induces procognitive effects through modulating hippocampal LTP and enhancing theta-gamma coupling in mice

Pytka,

Sałaciak,

Lustyk

et al. 2023

Preprint

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Neuropsychiatric disorders present with an array of emotional and behavioral symptoms, as well as cognitive deficits. Likely rooted in a complex pathophysiology involving glutamatergic neurotransmission imbalance, cognitive deficits frequently elude treatment by current pharmacotherapies. This highlights the pressing need for innovative drugs specifically targeting and ameliorating cognitive deficits in neuropsychiatric disorders. Here we show that HBK-15, a multimodal compound, exhibits robust antiamnesic properties across several MK-801-induced mouse models of memory deficits, likely through counteracting LTP decline and enhancing theta-gamma coupling in the hippocampus. HBK-15 has shown efficacy in mitigating MK-801-induced cognitive deficits across recognition, emotional, and spatial memory domains without impacting motor skill learning. Its protective effects spanned the encoding, consolidation, and retrieval phases of memory processing. Furthermore, the test compound counteracted the decrease in the hippocampal LTP magnitude caused by MK-801, probably via influencing the L-type voltage-gated calcium channels (Cav1.2). Interestingly, HBK-15 and MK-801 exhibited opposing effects on the coupling between theta and gamma oscillations in the hippocampus. The promotion of theta-gamma coupling by HBK-15 suggests that the compound holds promise for enhancing learning and memory processes. Overall, our research underscores the potential of HBK-15 and compounds of a similar receptor profile in developing effective therapeutic strategies for cognitive deficits in neuropsychiatric conditions such as depression or schizophrenia.

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Cellular and Molecular Aspects of Short-Term and Long-Term Memory from Molluscan Systems

Cited by 3 publications

References 26 publications

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

Critical Period of Memory Enhancement during Taste Avoidance Conditioning in Lymnaea stagnalis

The shadow-induced withdrawal response, dermal photoreceptors, and their input to the higher-order interneuron RPeD11 in the pond snailLymnaea stagnalis

HBK-15, a multimodal compound, induces procognitive effects through modulating hippocampal LTP and enhancing theta-gamma coupling in mice

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