In recent years, the discovery of s tem cells in breas t milk, the fate of these cells in infants, and their potential role in regenerative medicine are taken into consideration. Due to the high plas ticity and differentiation capacity of these cells as well as the possibility of their differentiation into neural-like cells, the role of these cells during infancy and the possibility of their migration along the intes tinal-brain axis are extensively inves tigated. Conclusion: Considering the attractive properties of breas t milk, the possible role of milk s tem cells in the amelioration of pediatric neurological disorders in newborns, and the possibility of increasing neonatal intelligence quotient by migration to the neonatal brain, and their therapeutic potentials in regenerative medicine were reviewed.d