Cellular dataset for: The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Zacharias, Amanda; Murray, John Isaac; Preston, Elicia; Crawford, Jeremy; Rumley, Jonathan; Amom, Prativa; Anderson, Breana; Sivaramakrishnan, Priya; Patel, Shaili; Bennett, Barrington; Lavon, Teddy; Peng, Felicia

doi:10.5061/dryad.zs7h44j86

2021

DOI: 10.5061/dryad.zs7h44j86

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Cellular dataset for: The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Amanda Zacharias,

John Isaac Murray,

Elicia Preston

et al.

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The anterior Hox geneceh-13andelt-1/GATAactivate the posterior Hox genesnob-1andphp-3to specify posterior lineages in theC. elegansembryo

Preston

et al. 2021

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Hox transcription factors play a conserved role in specifying positional identity during animal development, with posterior Hox genes typically repressing the expression of more anterior Hox genes. Here, we dissect the regulation of the posterior Hox genes nob-1 and php-3 in the nematode C. elegans. We show that nob-1 and php-3 are co-expressed in gastrulation-stage embryos in cells that previously expressed the anterior Hox gene ceh-13. This expression is controlled by several partially redundant transcriptional enhancers. Surprisingly, these enhancers require ceh-13 for expression, providing an example of an anterior Hox gene positively regulating a posterior Hox gene. Several other regulators including elt-1/GATA, ceh-20/ceh-40/Pbx, unc-62/Meis, pop-1/TCF, ceh-36/Otx and unc-30/Pitx also act positively through nob-1/php-3 enhancers. We identified defects in both cell position and cell division patterns in ceh-13 and nob-1;php-3 mutants, suggesting that these factors regulate lineage identity in addition to positional identity. Taken together, our results highlight the complexity and unexpected flexibility of Hox gene regulation and function.

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The anterior Hox geneceh-13andelt-1/GATAactivate the posterior Hox genesnob-1andphp-3to specify posterior lineages in theC. elegansembryo

Preston

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

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Cellular dataset for: The anterior Hox gene ceh-13 and elt-1/GATA activate the posterior Hox genes nob-1 and php-3 to specify posterior lineages in the C. elegans embryo

Cited by 1 publication

References 1 publication

The anterior Hox geneceh-13andelt-1/GATAactivate the posterior Hox genesnob-1andphp-3to specify posterior lineages in theC. elegansembryo

The anterior Hox geneceh-13andelt-1/GATAactivate the posterior Hox genesnob-1andphp-3to specify posterior lineages in theC. elegansembryo

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