Cellular DNA content and prognosis in surgically treated squamous carcinoma of the larynx

Cooke, LD; Cooke, TG; Forster, G.; Helliwell, T.R.; Stell, P. M.

doi:10.1038/bjc.1991.221

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…Aneuploidy of tumor edge was significantly more common among survivors. Cooke et al [22] demonstrated no significant difference between survival rates of surgically treated patients with diploid versus aneuploid laryngeal tumors. In another study by Rua and colleagues [23], tumor ploidy was not found to affect survival rate significantly when considered singly.…”

Section: Discussionmentioning

confidence: 98%

Real-time PCR hTERT mRNA pattern in tumor core, edge, resection margin, and lymph nodes in laryngeal tumors: Relation to proliferative index and impact on prognosis

Eissa

Kenawy

Moteleb

et al. 2005

Clinical Biochemistry

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Section: Discussionmentioning

confidence: 98%

Real-time PCR hTERT mRNA pattern in tumor core, edge, resection margin, and lymph nodes in laryngeal tumors: Relation to proliferative index and impact on prognosis

Eissa

Kenawy

Moteleb

et al. 2005

Clinical Biochemistry

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“…Wolf et al (1994) concluded that supraglottic tumours with a larger DNA content are more aggressive and produce multiple lymphatic metastases, having in general a worse prognosis. Cooke et al (1991) noted only a weak association between aneuploidy and the incidence of cervical node metastases in laryngeal carcinoma.…”

Section: Discussionmentioning

confidence: 92%

Prognostic factors in carcinoma of the larynx: relevance of DNA ploidy, S-fractions and localization of the tumour

et al. 1999

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The influence of the cell cycle profile and the site of the primary tumour on the overall survival were examined in 36 patients with squamous cell carcinoma of the larynx. DNA ploidy (p = 0.0091), the overall proliferative activity (p = 0.0001), the overall proliferative activity of diploid tumour cells (p = 0.0017) and primary tumour site (p = 0.0008) were found to be significant single prognostic factors of the overall survival. Multivariate analysis showed that only the overall proliferative activity was prognostically significant (p = 0.013). The results of the study show that the supraglottic site of the tumours correlates significantly with DNA ploidy (p = 0.0334) and the overall proliferative activity of tumour cells (p = 0.0159), whereas the correlation with proliferative activity of diploid tumour cells (p = 0.1416) has not been confirmed by this study. Glottic tumours showed a prognostically significant correlation with the overall proliferative activity (p = 0.0037) and proliferative activity of diploid tumour (p = 0.0054). Such a prognostic correlation was not found for DNA ploidy (p = 0.6542).

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Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer

Munck‐Wikland¹,

Kuylenstierna

et al. 1993

European Journal of Cancer Part B: Oral Oncology

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Cellular DNA content and prognosis in surgically treated squamous carcinoma of the larynx

Cited by 8 publications

References 27 publications

Real-time PCR hTERT mRNA pattern in tumor core, edge, resection margin, and lymph nodes in laryngeal tumors: Relation to proliferative index and impact on prognosis

Real-time PCR hTERT mRNA pattern in tumor core, edge, resection margin, and lymph nodes in laryngeal tumors: Relation to proliferative index and impact on prognosis

Prognostic factors in carcinoma of the larynx: relevance of DNA ploidy, S-fractions and localization of the tumour

Proliferating cell nuclear antigen (PCNA) expression and nuclear DNA content in predicting recurrence after radiotherapy of early glottic cancer

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